EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES
Aim. To study calcium-phosphor homeostasis and proinflammatory status of the cardiac valves bioprostheses (BP) recipients related to their interference with calcium degeneration of biomaterials.Material and methods. A retrospective assessment was performed of the calcium-phosphor metabolism and mark...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2015-07-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/232 |
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| author | N. V. Rutkovskaya O. N. Khryachkova A. S. Golovkin A. V. Ponasenko A. N. Stasev O. K. Kuzmina L. S. Barbarash |
| author_facet | N. V. Rutkovskaya O. N. Khryachkova A. S. Golovkin A. V. Ponasenko A. N. Stasev O. K. Kuzmina L. S. Barbarash |
| author_sort | N. V. Rutkovskaya |
| collection | DOAJ |
| description | Aim. To study calcium-phosphor homeostasis and proinflammatory status of the cardiac valves bioprostheses (BP) recipients related to their interference with calcium degeneration of biomaterials.Material and methods. A retrospective assessment was performed of the calcium-phosphor metabolism and markers of non-specific inflammatory response in recipients of BP in mitral position: with histologically confirmed calcification — group I (n=22) and with normal morphology and prosthesis function — group II (n=48).Results. In patients with BP degeneration, comparing to the recipients of biological prostheses with normal function at the background of moderate hypovitaminosis D (34,0 [21,0; 49,4] versus 40 [27,2; 54,0] pmol/L, р>0,05), osteoprotegerine deficiency (82,5 [44,2; 115,4] versus 113,5 [65,7; 191,3] pg/ml, р>0,05) and osteopontine (4,5 [3,3; 7,7] versus 5,2 [4,1; 7,2] ng/ml, р>0,05) there was statistically significant decrease of the bone isoenzyme of alkaline phosphatase (17,1 [12,2; 21,4] versus 22,3 [15,5; 30,5] E/L, р=0,01), and significant decrease of IL-8 (9,74 [9,19; 10,09] pg/ml versus 13,17 [9,72; 23,1] pg/ml, р=0,045) with general increase of proinflammatory serum markers activity.Conclusion. Into the group of probable predictors determining the tempos of BP calcification, the following could be included: specifics of recipient metabolic status defined by the activity of bone resorption processes, and local and systemic inflammation. |
| first_indexed | 2024-04-09T20:50:02Z |
| format | Article |
| id | doaj.art-87ed5fe68808445db2bd0dbe1ca2d776 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:50:02Z |
| publishDate | 2015-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj.art-87ed5fe68808445db2bd0dbe1ca2d7762023-03-29T21:23:24Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202015-07-01079810310.15829/1560-4071-2015-7-98-103232EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESESN. V. Rutkovskaya0O. N. Khryachkova1A. S. Golovkin2A. V. Ponasenko3A. N. Stasev4O. K. Kuzmina5L. S. Barbarash6Scientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoScientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoScientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoScientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoScientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoScientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoScientific-Research Institute of Complex Cardiovascular Diseases Problems of the Siberian Department RAMS, KemerovoAim. To study calcium-phosphor homeostasis and proinflammatory status of the cardiac valves bioprostheses (BP) recipients related to their interference with calcium degeneration of biomaterials.Material and methods. A retrospective assessment was performed of the calcium-phosphor metabolism and markers of non-specific inflammatory response in recipients of BP in mitral position: with histologically confirmed calcification — group I (n=22) and with normal morphology and prosthesis function — group II (n=48).Results. In patients with BP degeneration, comparing to the recipients of biological prostheses with normal function at the background of moderate hypovitaminosis D (34,0 [21,0; 49,4] versus 40 [27,2; 54,0] pmol/L, р>0,05), osteoprotegerine deficiency (82,5 [44,2; 115,4] versus 113,5 [65,7; 191,3] pg/ml, р>0,05) and osteopontine (4,5 [3,3; 7,7] versus 5,2 [4,1; 7,2] ng/ml, р>0,05) there was statistically significant decrease of the bone isoenzyme of alkaline phosphatase (17,1 [12,2; 21,4] versus 22,3 [15,5; 30,5] E/L, р=0,01), and significant decrease of IL-8 (9,74 [9,19; 10,09] pg/ml versus 13,17 [9,72; 23,1] pg/ml, р=0,045) with general increase of proinflammatory serum markers activity.Conclusion. Into the group of probable predictors determining the tempos of BP calcification, the following could be included: specifics of recipient metabolic status defined by the activity of bone resorption processes, and local and systemic inflammation.https://russjcardiol.elpub.ru/jour/article/view/232calcificationbioprosthesesinflammationcalcium-phosphor homeostasis |
| spellingShingle | N. V. Rutkovskaya O. N. Khryachkova A. S. Golovkin A. V. Ponasenko A. N. Stasev O. K. Kuzmina L. S. Barbarash EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES Российский кардиологический журнал calcification bioprostheses inflammation calcium-phosphor homeostasis |
| title | EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES |
| title_full | EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES |
| title_fullStr | EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES |
| title_full_unstemmed | EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES |
| title_short | EVALUATION OF THE CALCIUM-PHOSPHOR HOMEOSTASIS AND PROINFLAMMATORY STATUS OF RECIPIENTS WITH CALCIUM DEGENERATION OF CARDIAC VALVES PROSTHESES |
| title_sort | evaluation of the calcium phosphor homeostasis and proinflammatory status of recipients with calcium degeneration of cardiac valves prostheses |
| topic | calcification bioprostheses inflammation calcium-phosphor homeostasis |
| url | https://russjcardiol.elpub.ru/jour/article/view/232 |
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