Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats
Abstract Purpose To evaluate the normality pattern in functional tests of peripheral nerves. Methods Sixty female and sixty male Wistar rats were submitted to vibrissae movement and nictitating reflex for facial nerve; grooming test and grasping test for brachial plexus; and walking tracking test...
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2020-08-01
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| Series: | Acta Cirúrgica Brasileira |
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| Online Access: | http://www.scielo.br/pdf/acb/v35n7/1678-2674-acb-35-07-e202000702.pdf |
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| author | Renan Kleber Costa Teixeira Faustino Chaves Calvo Deivid Ramos dos Santos Nayara Pontes de Araújo Daniela Ferreira Tramontin Luís Vinícius Pires da Costa Rui Sergio Monteiro de Barros |
| author_facet | Renan Kleber Costa Teixeira Faustino Chaves Calvo Deivid Ramos dos Santos Nayara Pontes de Araújo Daniela Ferreira Tramontin Luís Vinícius Pires da Costa Rui Sergio Monteiro de Barros |
| author_sort | Renan Kleber Costa Teixeira |
| collection | DOAJ |
| description | Abstract Purpose To evaluate the normality pattern in functional tests of peripheral nerves. Methods Sixty female and sixty male Wistar rats were submitted to vibrissae movement and nictitating reflex for facial nerve; grooming test and grasping test for brachial plexus; and walking tracking test and horizontal ladder test for lumbar plexus. The tests were performed separately, with an interval of seven days between each. Results All animals showed the best score in vibrissae movement, nictitating reflex, grooming test, and horizontal ladder test. The best score was acquired for the first time in more than 90% of animals. The mean of strength on the grasping test was 133.46±12.08g for the right and 121.74±8.73g for the left anterior paw. There was a difference between the right and left sides. There was no difference between the groups according to sex. There is no statistical difference comparing all functional indexes between sex, independent of the side analyzed. The peroneal functional index showed higher levels than the sciatic and tibial functional index on both sides and sex. Conclusions The behavioral and functional assessment of peripheral nerve regeneration are low-cost, easy to perform, and reliable tests. However, they need to be performed by experienced researchers to avoid misinterpretation. |
| first_indexed | 2024-12-22T07:45:14Z |
| format | Article |
| id | doaj.art-87edc664979c4bc7a16481739b4ce723 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T07:45:14Z |
| publishDate | 2020-08-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-87edc664979c4bc7a16481739b4ce7232022-12-21T18:33:39ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502020-08-0135710.1590/s0102-865020200070000002Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar ratsRenan Kleber Costa Teixeirahttps://orcid.org/0000-0002-5079-297XFaustino Chaves Calvohttps://orcid.org/0000-0002-7427-7200Deivid Ramos dos Santoshttps://orcid.org/0000-0002-7558-0359Nayara Pontes de Araújohttps://orcid.org/0000-0002-9529-9556Daniela Ferreira Tramontinhttps://orcid.org/0000-0002-0399-4034Luís Vinícius Pires da Costahttps://orcid.org/0000-0002-2832-5566Rui Sergio Monteiro de Barroshttps://orcid.org/0000-0002-4841-2894Abstract Purpose To evaluate the normality pattern in functional tests of peripheral nerves. Methods Sixty female and sixty male Wistar rats were submitted to vibrissae movement and nictitating reflex for facial nerve; grooming test and grasping test for brachial plexus; and walking tracking test and horizontal ladder test for lumbar plexus. The tests were performed separately, with an interval of seven days between each. Results All animals showed the best score in vibrissae movement, nictitating reflex, grooming test, and horizontal ladder test. The best score was acquired for the first time in more than 90% of animals. The mean of strength on the grasping test was 133.46±12.08g for the right and 121.74±8.73g for the left anterior paw. There was a difference between the right and left sides. There was no difference between the groups according to sex. There is no statistical difference comparing all functional indexes between sex, independent of the side analyzed. The peroneal functional index showed higher levels than the sciatic and tibial functional index on both sides and sex. Conclusions The behavioral and functional assessment of peripheral nerve regeneration are low-cost, easy to perform, and reliable tests. However, they need to be performed by experienced researchers to avoid misinterpretation.http://www.scielo.br/pdf/acb/v35n7/1678-2674-acb-35-07-e202000702.pdfPeripheral Nerve InjuriesBehavioral ResearchBehavior Rating ScaleRatsIntroduction |
| spellingShingle | Renan Kleber Costa Teixeira Faustino Chaves Calvo Deivid Ramos dos Santos Nayara Pontes de Araújo Daniela Ferreira Tramontin Luís Vinícius Pires da Costa Rui Sergio Monteiro de Barros Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats Acta Cirúrgica Brasileira Peripheral Nerve Injuries Behavioral Research Behavior Rating Scale Rats Introduction |
| title | Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats |
| title_full | Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats |
| title_fullStr | Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats |
| title_full_unstemmed | Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats |
| title_short | Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats |
| title_sort | criteria for assessing peripheral nerve injury behavioral and functional assessment in non operated wistar rats |
| topic | Peripheral Nerve Injuries Behavioral Research Behavior Rating Scale Rats Introduction |
| url | http://www.scielo.br/pdf/acb/v35n7/1678-2674-acb-35-07-e202000702.pdf |
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