Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011
Cholera remains a major public health problem. To compare the relative contribution of strains from the environment with strains isolated from patients during outbreaks, we performed multilocus variable tandem repeat analyses on samples collected during the 2010 and 2011 outbreak seasons in 2 geogra...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2014-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/20/1/13-0796_article |
| _version_ | 1818525194084417536 |
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| author | Shah M. Rashed Andrew S. Azman Munirul Alam Shan Li David A. Sack J. Glenn Morris Ira Longini Abul Kasem Siddique Anwarul Iqbal Anwar Huq Rita R. Colwell R. Bradley Sack O. Colin Stine |
| author_facet | Shah M. Rashed Andrew S. Azman Munirul Alam Shan Li David A. Sack J. Glenn Morris Ira Longini Abul Kasem Siddique Anwarul Iqbal Anwar Huq Rita R. Colwell R. Bradley Sack O. Colin Stine |
| author_sort | Shah M. Rashed |
| collection | DOAJ |
| description | Cholera remains a major public health problem. To compare the relative contribution of strains from the environment with strains isolated from patients during outbreaks, we performed multilocus variable tandem repeat analyses on samples collected during the 2010 and 2011 outbreak seasons in 2 geographically distinct areas of Bangladesh. A total of 222 environmental and clinical isolates of V. cholerae O1 were systematically collected from Chhatak and Mathbaria. In Chhatak, 75 of 79 isolates were from the same clonal complex, in which extensive differentiation was found in a temporally consistent pattern of successive mutations at single loci. A total of 59 isolates were collected from 6 persons; most isolates from 1 person differed by sequential single-locus mutations. In Mathbaria, 60 of 84 isolates represented 2 separate clonal complexes. The small number of genetic lineages in isolates from patients, compared with those from the environment, is consistent with accelerated transmission of some strains among humans during an outbreak. |
| first_indexed | 2024-12-11T06:06:21Z |
| format | Article |
| id | doaj.art-87edf1dd608c4688afc869772d4f975c |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T06:06:21Z |
| publishDate | 2014-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-87edf1dd608c4688afc869772d4f975c2022-12-22T01:18:17ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-01-01201546010.3201/eid2001.130796Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011Shah M. RashedAndrew S. AzmanMunirul AlamShan LiDavid A. SackJ. Glenn MorrisIra LonginiAbul Kasem SiddiqueAnwarul IqbalAnwar HuqRita R. ColwellR. Bradley SackO. Colin StineCholera remains a major public health problem. To compare the relative contribution of strains from the environment with strains isolated from patients during outbreaks, we performed multilocus variable tandem repeat analyses on samples collected during the 2010 and 2011 outbreak seasons in 2 geographically distinct areas of Bangladesh. A total of 222 environmental and clinical isolates of V. cholerae O1 were systematically collected from Chhatak and Mathbaria. In Chhatak, 75 of 79 isolates were from the same clonal complex, in which extensive differentiation was found in a temporally consistent pattern of successive mutations at single loci. A total of 59 isolates were collected from 6 persons; most isolates from 1 person differed by sequential single-locus mutations. In Mathbaria, 60 of 84 isolates represented 2 separate clonal complexes. The small number of genetic lineages in isolates from patients, compared with those from the environment, is consistent with accelerated transmission of some strains among humans during an outbreak.https://wwwnc.cdc.gov/eid/article/20/1/13-0796_articlemultilocus sequence analysisinfectious disease outbreaksVibrio cholerabacteriaBangladeshVibrio cholerae |
| spellingShingle | Shah M. Rashed Andrew S. Azman Munirul Alam Shan Li David A. Sack J. Glenn Morris Ira Longini Abul Kasem Siddique Anwarul Iqbal Anwar Huq Rita R. Colwell R. Bradley Sack O. Colin Stine Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011 Emerging Infectious Diseases multilocus sequence analysis infectious disease outbreaks Vibrio cholera bacteria Bangladesh Vibrio cholerae |
| title | Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011 |
| title_full | Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011 |
| title_fullStr | Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011 |
| title_full_unstemmed | Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011 |
| title_short | Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011 |
| title_sort | genetic variation of vibrio cholerae during outbreaks bangladesh 2010 2011 |
| topic | multilocus sequence analysis infectious disease outbreaks Vibrio cholera bacteria Bangladesh Vibrio cholerae |
| url | https://wwwnc.cdc.gov/eid/article/20/1/13-0796_article |
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