Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews
A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subse...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2018-01-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/5472 |
| _version_ | 1819041103668576256 |
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| author | Syahrul Sazliyana Shaharir Adawiyah Jamil Sumitro Kosasih Low Soo Fin Radhika Sridharan Suria Hayati Md Pauzi |
| author_facet | Syahrul Sazliyana Shaharir Adawiyah Jamil Sumitro Kosasih Low Soo Fin Radhika Sridharan Suria Hayati Md Pauzi |
| author_sort | Syahrul Sazliyana Shaharir |
| collection | DOAJ |
| description | A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis. He responded well to the corticosteroids, and finally, azathioprine was added as a steroid-sparing agent. Including our series, there are 103 cases of symptomatic muscle involvement in sarcoidosis patients published in the English literature to date. Further pool analysis of the cases will be reported in this review. |
| first_indexed | 2024-12-21T09:19:41Z |
| format | Article |
| id | doaj.art-87ef80605c4d48fbbac2cf7e73952478 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-21T09:19:41Z |
| publishDate | 2018-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-87ef80605c4d48fbbac2cf7e739524782022-12-21T19:09:02ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942018-01-0155125238Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature ReviewsSyahrul Sazliyana Shaharir0Adawiyah Jamil1Sumitro Kosasih2Low Soo Fin3Radhika Sridharan4Suria Hayati Md Pauzi5Department of Internal Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.Department of Internal Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.Department of Internal Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.Department of Radiology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.Department of Radiology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.Department of Pathology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis. He responded well to the corticosteroids, and finally, azathioprine was added as a steroid-sparing agent. Including our series, there are 103 cases of symptomatic muscle involvement in sarcoidosis patients published in the English literature to date. Further pool analysis of the cases will be reported in this review.https://acta.tums.ac.ir/index.php/acta/article/view/5472GranulomaMyopathySarcoidosisSubcutaneous nodules |
| spellingShingle | Syahrul Sazliyana Shaharir Adawiyah Jamil Sumitro Kosasih Low Soo Fin Radhika Sridharan Suria Hayati Md Pauzi Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews Acta Medica Iranica Granuloma Myopathy Sarcoidosis Subcutaneous nodules |
| title | Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews |
| title_full | Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews |
| title_fullStr | Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews |
| title_full_unstemmed | Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews |
| title_short | Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews |
| title_sort | sarcoid myopathy mimicking polymyositis a case report and pool analysis of the literature reviews |
| topic | Granuloma Myopathy Sarcoidosis Subcutaneous nodules |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/5472 |
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