Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma

Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma

Abstract Background Ewing sarcoma (EWS) is an aggressive sarcoma with few treatment options for patients with relapsed disease. Cyclin‐dependent kinase 4 (CDK4) is a genomic vulnerability in EWS that is synergistic with IGF‐1R inhibition in preclinical studies. We present the results of a phase 2 st...

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Bibliográfalaš dieđut
Váldodahkkit: David S. Shulman, Priscilla Merriam, Edwin Choy, Lillian M. Guenther, Kerri L. Cavanaugh, Pei‐Chi Kao, Andrew Posner, Ketki Bhushan, Grace Fairchild, Emma Barker, Kelly Klega, Kimberly Stegmaier, Brian D. Crompton, Wendy B. London, Steven G. DuBois
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Wiley 2023-07-01
Ráidu:Cancer Medicine
Fáttát:
CDK4/6
Ewing sarcoma
ganitumab
IGF‐1R
palbociclib
Liŋkkat:https://doi.org/10.1002/cam4.6208

Interneahtta

https://doi.org/10.1002/cam4.6208

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