Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism
Aim. To study effects of different treatments on erectile and endothelial functions in patients with erectile dysfunction (ED) and age-related hypogonadism (HG). Material and methods. The study included 66 males with ED who had clinical and laboratory signs of HG. All the patients were examined usin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2008-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30257 |
| _version_ | 1818453169171070976 |
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| author | E B Mazo S I Gamidov E M Sotnikova E B Mazo S I Gamidov E M Sotnikova |
| author_facet | E B Mazo S I Gamidov E M Sotnikova E B Mazo S I Gamidov E M Sotnikova |
| author_sort | E B Mazo |
| collection | DOAJ |
| description | Aim. To study effects of different treatments on erectile and endothelial functions in patients with erectile dysfunction (ED) and age-related hypogonadism (HG).
Material and methods. The study included 66 males with ED who had clinical and laboratory signs of HG. All the patients were examined using questionnaires (international index of erectile function, AMS), blood hormones tests. Endothelial function was assessed with postcompression tests on the cavernous arteries and blood homocystein assay. All the patients were divided into two matched groups. Group 1 (20 males, mean age 54.6 ± 11.5 years) received androgens only, replacement therapy consisted of testosterone undecanoate (Nebido, Shering) 1000 mg each 10-12 weeks intramuscularly, interval between the first and second injection was 6 weeks. Group 2 (46 males, mean age 53.98 ± 10.03 years) was given combined treatment (androgens and PDE 5 inhibitors), wardenafil (Levitra, Buer Shering Pharma) was used in a dose 20 mg. The treatment lasted 6 months.
Results. AMS points decreased in group 1 from 38.3 ± 0.29 to 29.2 ± 0.32 , in group 2 - from 39.02 ± 0.21 to 28.6 ± 0.95, while testosterone rose from 9.86 ± 0.4 to 17.77 ± 0.42 and 9.35 ± 0.25 to 17.21 ± 0.63 nmol, respectively. Homocystein lowering was significantly more manifest in group 2. EF index in group 2 rose from 11.4 ± 0.77 to 25.54 ± 0.25 points versus 11.2 ± 1.01 to 23.95 ± 0.71 points in group 1, improvement of EF in group 2 occurred sooner. Endothelial function by diameter of the cavernous arteries differed after treatment in group 1 and 2 (19.55 ± 2.88 to 39.2 ± 0.84% and 19.51 ± 1.28 to 48.5 ± 1.76, respectively, p < 0.001).
Conclusion. Combined therapy improves blood homocistein, acts faster and stronger on endothelial and erectile functions and can be recommended as first line for ED and HG patients. |
| first_indexed | 2024-12-14T21:34:43Z |
| format | Article |
| id | doaj.art-87f0a80a9c49455ba3d47a80ea79ad41 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-14T21:34:43Z |
| publishDate | 2008-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-87f0a80a9c49455ba3d47a80ea79ad412022-12-21T22:46:36Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422008-12-018012596327284Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadismE B MazoS I GamidovE M SotnikovaE B MazoS I GamidovE M SotnikovaAim. To study effects of different treatments on erectile and endothelial functions in patients with erectile dysfunction (ED) and age-related hypogonadism (HG). Material and methods. The study included 66 males with ED who had clinical and laboratory signs of HG. All the patients were examined using questionnaires (international index of erectile function, AMS), blood hormones tests. Endothelial function was assessed with postcompression tests on the cavernous arteries and blood homocystein assay. All the patients were divided into two matched groups. Group 1 (20 males, mean age 54.6 ± 11.5 years) received androgens only, replacement therapy consisted of testosterone undecanoate (Nebido, Shering) 1000 mg each 10-12 weeks intramuscularly, interval between the first and second injection was 6 weeks. Group 2 (46 males, mean age 53.98 ± 10.03 years) was given combined treatment (androgens and PDE 5 inhibitors), wardenafil (Levitra, Buer Shering Pharma) was used in a dose 20 mg. The treatment lasted 6 months. Results. AMS points decreased in group 1 from 38.3 ± 0.29 to 29.2 ± 0.32 , in group 2 - from 39.02 ± 0.21 to 28.6 ± 0.95, while testosterone rose from 9.86 ± 0.4 to 17.77 ± 0.42 and 9.35 ± 0.25 to 17.21 ± 0.63 nmol, respectively. Homocystein lowering was significantly more manifest in group 2. EF index in group 2 rose from 11.4 ± 0.77 to 25.54 ± 0.25 points versus 11.2 ± 1.01 to 23.95 ± 0.71 points in group 1, improvement of EF in group 2 occurred sooner. Endothelial function by diameter of the cavernous arteries differed after treatment in group 1 and 2 (19.55 ± 2.88 to 39.2 ± 0.84% and 19.51 ± 1.28 to 48.5 ± 1.76, respectively, p < 0.001). Conclusion. Combined therapy improves blood homocistein, acts faster and stronger on endothelial and erectile functions and can be recommended as first line for ED and HG patients.https://ter-arkhiv.ru/0040-3660/article/view/30257erectile dysfunctionhypogonadismcombined treatmentandrogensphosphodiesterase inhibitors of type 5 |
| spellingShingle | E B Mazo S I Gamidov E M Sotnikova E B Mazo S I Gamidov E M Sotnikova Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism Терапевтический архив erectile dysfunction hypogonadism combined treatment androgens phosphodiesterase inhibitors of type 5 |
| title | Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism |
| title_full | Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism |
| title_fullStr | Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism |
| title_full_unstemmed | Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism |
| title_short | Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism |
| title_sort | effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism |
| topic | erectile dysfunction hypogonadism combined treatment androgens phosphodiesterase inhibitors of type 5 |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30257 |
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