$Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats$

Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats

Abstract Background Fractures heal through a process that involves angiogenesis and osteogenesis but may also lead to non-union or delayed healing. Bone marrow mesenchymal stem cells (BMSCs) have been reported to play a pivotal role in bone formation and vascular regeneration and the p75 neurotrophi...

Full description

Bibliographic Details
Main Authors:	Zhifeng Wu, Yongming Yang, Ming Wang
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Series:	Journal of Orthopaedic Surgery and Research
Subjects:	Fracture healing BMSCs p75NTR Sortilin
Online Access:	https://doi.org/10.1186/s13018-024-04653-8

Similar Items

Expression of NGF/proNGF and Their Receptors TrkA, p75<sup>NTR</sup> and Sortilin in Melanoma
by: Mark Marsland, et al.
Published: (2022-04-01)

Upregulation of p75NTR by Histone Deacetylase Inhibitors Sensitizes Human Neuroblastoma Cells to Targeted Immunotoxin-Induced Apoptosis
by: Simona Dedoni, et al.
Published: (2022-03-01)

Immunohistochemical Detection of p75 Neurotrophin Receptor (p75-NTR) in Follicular and Plexiform Ameloblastoma
by: YOITHAPPRABHUNATH THUKANAYAKANPALAYAM RAGUNATHAN, et al.
Published: (2016-08-01)

Overexpression of p75<sup>NTR</sup> in Human Seminoma: A New Biomarker?
by: Anna Perri, et al.
Published: (2021-06-01)

Schwann Cell Apoptosis and p75NTR siRNA
by: Masoumeh Firouzi, et al.
Published: (2011-03-01)

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression
by: Nádia P. Gonçalves, et al.
Published: (2019-05-01)

Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma
by: Dijian Shen, et al.
Published: (2019-09-01)

Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis
by: Nickoleta Delivanoglou, et al.
Published: (2020-01-01)

Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin
by: Nádia P. Gonçalves, et al.
Published: (2020-10-01)

Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors
by: Anna M. Conti, et al.
Published: (2004-02-01)

The expression system affects the binding affinity between p75NTR and proNGF
by: Mami Hino, et al.
Published: (2024-07-01)

From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion?
by: Sabine Wislet, et al.
Published: (2018-08-01)

ProBDNF and its receptors in immune-mediated inflammatory diseases: novel insights into the regulation of metabolism and mitochondria
by: Qiao Li, et al.
Published: (2023-04-01)

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
by: Viviana Pérez, et al.
Published: (2019-09-01)

ASPH Regulates Osteogenic Differentiation and Cellular Senescence of BMSCs
by: Hui Peng, et al.
Published: (2020-09-01)

Role and mechanism of NTR p75 receptor in oxidative damage of retinal pigment epithelium cells
by: Xin Gu, et al.
Published: (2018-01-01)

PEGylated CuInS2/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75NTR/MAPK pathway
by: Zhiwen Yang, et al.
Published: (2021-01-01)

Opposite Expression Patterns of Spry3 and p75NTR in Cerebellar Vermis Suggest a Male-Specific Mechanism of Autism Pathogenesis
by: Zhenfei Ning, et al.
Published: (2019-06-01)

p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
by: Bo Xie, et al.
Published: (2023-11-01)

Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice
by: Juan Pablo Zanin, et al.
Published: (2023-05-01)

The Effect of Interaction NGF/p75<sup>NTR</sup> in Sperm Cells: A Rabbit Model
by: Cesare Castellini, et al.
Published: (2022-03-01)

Pro Nerve Growth Factor and Its Receptor p75NTR Activate Inflammatory Responses in Synovial Fibroblasts: A Novel Targetable Mechanism in Arthritis
by: Luciapia Farina, et al.
Published: (2022-03-01)

Identification and characterization of the two-component NtrY/NtrX regulatory system in Azospirillum brasilense
by: M.L. Ishida, et al.
Published: (2002-06-01)

Reduced anxiety-like behavior and altered hippocampal morphology in female p75NTR exon IV-/- mice.
by: Zoe ePuschban, et al.
Published: (2016-06-01)

The p75NTR-mediated effect of nerve growth factor in L6C5 myogenic cells
by: Alessandra de Perini, et al.
Published: (2017-12-01)

Cartilage fragments combined with BMSCs-Derived exosomes can promote tendon-bone healing after ACL reconstruction
by: Chi Zhang, et al.
Published: (2023-12-01)

Association of the <i>p75<sup>NTR</sup></i> Ser205Leu Polymorphism with Asymptomatic HTLV-1 Infection
by: Maria Alice Freitas Queiroz, et al.
Published: (2022-05-01)

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathway
by: Kai Hang, et al.
Published: (2021-10-01)

Modulation of p75<sup>NTR</sup> on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model
by: Sally L. Elshaer, et al.
Published: (2021-01-01)

TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs
by: Xiaonan Liang, et al.
Published: (2021-08-01)

p75NTR antibody-conjugated microspheres: an approach to guided tissue regeneration by selective recruitment of endogenous periodontal ligament cells
by: Xuqiang Zou, et al.
Published: (2024-01-01)

The Nerve Growth Factor Receptor (NGFR/p75<sup>NTR</sup>): A Major Player in Alzheimer’s Disease
by: Francesco Bruno, et al.
Published: (2023-02-01)

Etiological Roles of p75<sup>NTR</sup> in a Mouse Model of Wet Age-Related Macular Degeneration
by: Paula Virginia Subirada, et al.
Published: (2023-01-01)

GOLM1 Stimulation of Glutamine Metabolism Promotes Osteoporosis via Inhibiting Osteogenic Differentiation of BMSCs
by: Guangsi Shen, et al.
Published: (2018-11-01)

Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline
by: Tomoko T. Asai, et al.
Published: (2020-03-01)

ZDHHC16 restrains osteogenic differentiation of bone marrow mesenchymal stem cells by inhibiting phosphorylation of CREB
by: Zhiwei Li, et al.
Published: (2023-01-01)

Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing
by: Siyu Fan, et al.
Published: (2023-06-01)

Nanog/NFATc1/Osterix signaling pathway-mediated promotion of bone formation at the tendon–bone interface after ACL reconstruction with De-BMSCs transplantation
by: Kai Tie, et al.
Published: (2021-11-01)

Surface micropatterning of 3D printed PCL scaffolds promotes osteogenic differentiation of BMSCs and regulates macrophage M2 polarization
by: Weihua Huang, et al.
Published: (2024-03-01)

Collagen-Derived Di-Peptide, Prolylhydroxyproline (Pro-Hyp): A New Low Molecular Weight Growth-Initiating Factor for Specific Fibroblasts Associated With Wound Healing
by: Kenji Sato, et al.
Published: (2020-11-01)