Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor
We report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1325336/full |
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| author | Bhaswati Choudhury Bhaswati Choudhury John A. Lednicky John A. Lednicky Julia C. Loeb Julia C. Loeb Sherlie Portugal Sherlie Portugal Subrata Roy Subrata Roy |
| author_facet | Bhaswati Choudhury Bhaswati Choudhury John A. Lednicky John A. Lednicky Julia C. Loeb Julia C. Loeb Sherlie Portugal Sherlie Portugal Subrata Roy Subrata Roy |
| author_sort | Bhaswati Choudhury |
| collection | DOAJ |
| description | We report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere as input gas, eliminating the need of source gas tanks. Iterative CPPR exposure time experiments were performed on inoculated material samples in 3 operating volumes. Minimum CPPR exposure times of 5–15 min resulted in 4–5 log reduction of SARS CoV-2 and its surrogate on representative material samples. Ozone concentration and CPPR energy requirements for virus inactivation are documented. Difference in disinfection requirements in porous and non-porous material samples is discussed along with initial scaling studies using the CPPR in 3 operating volumes. The results of this feasibility study, along with existing literature on ozone and CPPR decontamination, show the potential of the CPPR as a powerful technology to reduce fomite transmission of enveloped respiratory virus-induced infectious diseases such as COVID-19. The CPPR can overcome limitations of high temperatures, long exposure times, bulky equipment, and toxic residuals related to conventional decontamination technologies. |
| first_indexed | 2024-03-07T19:40:44Z |
| format | Article |
| id | doaj.art-87f2b4e8904648c58078f24c82e8947c |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-07T19:40:44Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-87f2b4e8904648c58078f24c82e8947c2024-02-29T05:33:48ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-02-011210.3389/fbioe.2024.13253361325336Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactorBhaswati Choudhury0Bhaswati Choudhury1John A. Lednicky2John A. Lednicky3Julia C. Loeb4Julia C. Loeb5Sherlie Portugal6Sherlie Portugal7Subrata Roy8Subrata Roy9SurfPlasma, Inc., Gainesville, FL, United StatesEmerging Pathogens Institute, University of Florida, Gainesville, FL, United StatesEmerging Pathogens Institute, University of Florida, Gainesville, FL, United StatesDepartment of Environmental and Global Health, University of Florida, Gainesville, FL, United StatesEmerging Pathogens Institute, University of Florida, Gainesville, FL, United StatesDepartment of Environmental and Global Health, University of Florida, Gainesville, FL, United StatesSurfPlasma, Inc., Gainesville, FL, United StatesSchool of Electrical Engineering, Technological University of Panama, Panama City, PanamaSurfPlasma, Inc., Gainesville, FL, United StatesDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, United StatesWe report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere as input gas, eliminating the need of source gas tanks. Iterative CPPR exposure time experiments were performed on inoculated material samples in 3 operating volumes. Minimum CPPR exposure times of 5–15 min resulted in 4–5 log reduction of SARS CoV-2 and its surrogate on representative material samples. Ozone concentration and CPPR energy requirements for virus inactivation are documented. Difference in disinfection requirements in porous and non-porous material samples is discussed along with initial scaling studies using the CPPR in 3 operating volumes. The results of this feasibility study, along with existing literature on ozone and CPPR decontamination, show the potential of the CPPR as a powerful technology to reduce fomite transmission of enveloped respiratory virus-induced infectious diseases such as COVID-19. The CPPR can overcome limitations of high temperatures, long exposure times, bulky equipment, and toxic residuals related to conventional decontamination technologies.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1325336/fullplasmaCOVID-19SARS CoV-2ozonedisinfectionsterilization |
| spellingShingle | Bhaswati Choudhury Bhaswati Choudhury John A. Lednicky John A. Lednicky Julia C. Loeb Julia C. Loeb Sherlie Portugal Sherlie Portugal Subrata Roy Subrata Roy Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor Frontiers in Bioengineering and Biotechnology plasma COVID-19 SARS CoV-2 ozone disinfection sterilization |
| title | Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor |
| title_full | Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor |
| title_fullStr | Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor |
| title_full_unstemmed | Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor |
| title_short | Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor |
| title_sort | inactivation of sars cov 2 on porous and nonporous surfaces by compact portable plasma reactor |
| topic | plasma COVID-19 SARS CoV-2 ozone disinfection sterilization |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1325336/full |
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