Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting

Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting

Tetraspan proteins are significantly enriched in the membranes of exosomal vesicles (EVs) and their extracellular domains are attractive targets for engineering towards specific antigen recognition units. To enhance the tolerance of a tetraspanin fold to modification, we achieved significant thermal...

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Bibliographic Details
Main Authors: Stefan Vogt, Gerhard Stadlmayr, Katharina Stadlbauer, Flávio Sádio, Peter Andorfer, Johannes Grillari, Florian Rüker, Gordana Wozniak-Knopp
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
CD81 large extracellular loop
peptide grafting
antigen recognition unit
stability engineering
Online Access:http://www.mdpi.com/1999-4923/10/3/138

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