Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive
IntroductionSemantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A−) on positron emission tomography (PET).MethodThis study examines the association between SI and plasma – based biomarkers. One...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1179205/full |
| _version_ | 1797754527515934720 |
|---|---|
| author | Rosie E. Curiel Cid Alexandra Ortega Elizabeth A. Crocco Diana Hincapie Karen N. McFarland Ranjan Duara David Vaillancourt Steven T. DeKosky Glenn Smith Efrosyni Sfakianaki Monica Rosselli Warren W. Barker Malek Adjouadi Yarlenis Barreto Yuleidys Feito David A. Loewenstein |
| author_facet | Rosie E. Curiel Cid Alexandra Ortega Elizabeth A. Crocco Diana Hincapie Karen N. McFarland Ranjan Duara David Vaillancourt Steven T. DeKosky Glenn Smith Efrosyni Sfakianaki Monica Rosselli Warren W. Barker Malek Adjouadi Yarlenis Barreto Yuleidys Feito David A. Loewenstein |
| author_sort | Rosie E. Curiel Cid |
| collection | DOAJ |
| description | IntroductionSemantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A−) on positron emission tomography (PET).MethodThis study examines the association between SI and plasma – based biomarkers. One hundred and twenty-eight participants received SiMoA derived measures of plasma pTau-181, ratio of two amyloid-β peptide fragments (Aβ42/Aβ40), Neurofilament Light protein (NfL), Glial Fibrillary Acidic Protein (GFAP), ApoE genotyping, and amyloid PET imaging.ResultsThe aMCI A+ (n = 42) group had a higher percentage of ApoE ɛ4 carriers, and greater levels of pTau-181 and SI, than Cognitively Unimpaired (CU) A− participants (n = 25). CU controls did not differ from aMCI A− (n = 61) on plasma biomarkers or ApoE genotype. Logistic regression indicated that ApoE ɛ4 positivity, pTau-181, and SI were independent differentiating predictors (Correct classification = 82.0%; Sensitivity = 71.4%; Specificity = 90.2%) in identifying A+ from A− aMCI cases.DiscussionA combination of plasma biomarkers, ApoE positivity and SI had high specificity in identifying A+ from A− aMCI cases. |
| first_indexed | 2024-03-12T17:34:41Z |
| format | Article |
| id | doaj.art-87f35fb535f44e528cdd626c4e68d841 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T17:34:41Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-87f35fb535f44e528cdd626c4e68d8412023-08-04T12:21:27ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.11792051179205Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positiveRosie E. Curiel Cid0Alexandra Ortega1Elizabeth A. Crocco2Diana Hincapie3Karen N. McFarland4Ranjan Duara5David Vaillancourt6Steven T. DeKosky7Glenn Smith8Efrosyni Sfakianaki9Monica Rosselli10Warren W. Barker11Malek Adjouadi12Yarlenis Barreto13Yuleidys Feito14David A. Loewenstein15Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurology and the Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, United StatesDepartment of Neurology and the Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, United StatesDepartment of Applied Physiology and Kinesiology, Gainesville, FL, United StatesDepartment of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Psychology, Florida Atlantic University, Boca Raton, FL, United StatesWien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center, Miami, FL, United StatesCenter for Advanced Technology and Education, Florida International University, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesIntroductionSemantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A−) on positron emission tomography (PET).MethodThis study examines the association between SI and plasma – based biomarkers. One hundred and twenty-eight participants received SiMoA derived measures of plasma pTau-181, ratio of two amyloid-β peptide fragments (Aβ42/Aβ40), Neurofilament Light protein (NfL), Glial Fibrillary Acidic Protein (GFAP), ApoE genotyping, and amyloid PET imaging.ResultsThe aMCI A+ (n = 42) group had a higher percentage of ApoE ɛ4 carriers, and greater levels of pTau-181 and SI, than Cognitively Unimpaired (CU) A− participants (n = 25). CU controls did not differ from aMCI A− (n = 61) on plasma biomarkers or ApoE genotype. Logistic regression indicated that ApoE ɛ4 positivity, pTau-181, and SI were independent differentiating predictors (Correct classification = 82.0%; Sensitivity = 71.4%; Specificity = 90.2%) in identifying A+ from A− aMCI cases.DiscussionA combination of plasma biomarkers, ApoE positivity and SI had high specificity in identifying A+ from A− aMCI cases.https://www.frontiersin.org/articles/10.3389/fneur.2023.1179205/fullmild cognitive impairmentsemantic intrusionsplasma biomarkerssematic interferenceinhibitory controlp-tau amyloid |
| spellingShingle | Rosie E. Curiel Cid Alexandra Ortega Elizabeth A. Crocco Diana Hincapie Karen N. McFarland Ranjan Duara David Vaillancourt Steven T. DeKosky Glenn Smith Efrosyni Sfakianaki Monica Rosselli Warren W. Barker Malek Adjouadi Yarlenis Barreto Yuleidys Feito David A. Loewenstein Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive Frontiers in Neurology mild cognitive impairment semantic intrusions plasma biomarkers sematic interference inhibitory control p-tau amyloid |
| title | Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive |
| title_full | Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive |
| title_fullStr | Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive |
| title_full_unstemmed | Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive |
| title_short | Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive |
| title_sort | semantic intrusion errors are associated with plasma ptau 181 among persons with amnestic mild cognitive impairment who are amyloid positive |
| topic | mild cognitive impairment semantic intrusions plasma biomarkers sematic interference inhibitory control p-tau amyloid |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1179205/full |
| work_keys_str_mv | AT rosieecurielcid semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT alexandraortega semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT elizabethacrocco semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT dianahincapie semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT karennmcfarland semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT ranjanduara semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT davidvaillancourt semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT steventdekosky semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT glennsmith semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT efrosynisfakianaki semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT monicarosselli semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT warrenwbarker semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT malekadjouadi semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT yarlenisbarreto semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT yuleidysfeito semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive AT davidaloewenstein semanticintrusionerrorsareassociatedwithplasmaptau181amongpersonswithamnesticmildcognitiveimpairmentwhoareamyloidpositive |