Vancomycin: the need to suit serum concentrations in hemodialysis patients
The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several ha...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200019&lng=en&tlng=en |
| _version_ | 1830271795412860928 |
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| author | Lívia Luize Marengo Fernando de Sá Del Fiol Sara de Jesus Oliveira Celso Nakagawa Eduardo Leite Croco Silvio Barberato-Filho Marcela Pellegrini Peçanha Douglas Felix da Silva Maria Inês de Toledo |
| author_facet | Lívia Luize Marengo Fernando de Sá Del Fiol Sara de Jesus Oliveira Celso Nakagawa Eduardo Leite Croco Silvio Barberato-Filho Marcela Pellegrini Peçanha Douglas Felix da Silva Maria Inês de Toledo |
| author_sort | Lívia Luize Marengo |
| collection | DOAJ |
| description | The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the recommended value, indicating exposure to subtherapeutic doses and a higher risk for selecting resistant microorganisms. |
| first_indexed | 2024-12-18T23:12:42Z |
| format | Article |
| id | doaj.art-87f5a84e34624fb595437dec17f29f74 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-18T23:12:42Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-87f5a84e34624fb595437dec17f29f742022-12-21T20:48:18ZengElsevierBrazilian Journal of Infectious Diseases1678-439114220320810.1590/S1413-86702010000200019S1413-86702010000200019Vancomycin: the need to suit serum concentrations in hemodialysis patientsLívia Luize Marengo0Fernando de Sá Del Fiol1Sara de Jesus Oliveira2Celso Nakagawa3Eduardo Leite Croco4Silvio Barberato-Filho5Marcela Pellegrini Peçanha6Douglas Felix da Silva7Maria Inês de Toledo8Universidade de SorocabaUniversidade de SorocabaUniversidade de SorocabaConjunto Hospitalar de SorocabaConjunto Hospitalar de SorocabaUniversidade de SorocabaPontifícia Universidade Católica de São PauloUniversidade de SorocabaUniversidade de SorocabaThe vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the recommended value, indicating exposure to subtherapeutic doses and a higher risk for selecting resistant microorganisms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200019&lng=en&tlng=envancomycinchronic renal failurehemodialysis |
| spellingShingle | Lívia Luize Marengo Fernando de Sá Del Fiol Sara de Jesus Oliveira Celso Nakagawa Eduardo Leite Croco Silvio Barberato-Filho Marcela Pellegrini Peçanha Douglas Felix da Silva Maria Inês de Toledo Vancomycin: the need to suit serum concentrations in hemodialysis patients Brazilian Journal of Infectious Diseases vancomycin chronic renal failure hemodialysis |
| title | Vancomycin: the need to suit serum concentrations in hemodialysis patients |
| title_full | Vancomycin: the need to suit serum concentrations in hemodialysis patients |
| title_fullStr | Vancomycin: the need to suit serum concentrations in hemodialysis patients |
| title_full_unstemmed | Vancomycin: the need to suit serum concentrations in hemodialysis patients |
| title_short | Vancomycin: the need to suit serum concentrations in hemodialysis patients |
| title_sort | vancomycin the need to suit serum concentrations in hemodialysis patients |
| topic | vancomycin chronic renal failure hemodialysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200019&lng=en&tlng=en |
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