Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera. Several groups have found global or antigen-specific skewing of IgG glycosylation, for example in autoimmune...

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Bibliographic Details
Main Authors: Gillian Dekkers, Louise Treffers, Rosina Plomp, Arthur E. H. Bentlage, Marcella de Boer, Carolien A. M. Koeleman, Suzanne N. Lissenberg-Thunnissen, Remco Visser, Mieke Brouwer, Juk Yee Mok, Hanke Matlung, Timo K. van den Berg, Wim J. E. van Esch, Taco W. Kuijpers, Diana Wouters, Theo Rispens, Manfred Wuhrer, Gestur Vidarsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin G glycosylation
Fc gamma receptor
antibody-dependent cellular cytotoxicity
complement
antibody effector functions
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00877/full

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