Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide
Considering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded co...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Chemical Society of Ethiopia
2012-12-01
|
| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://www.ajol.info/index.php/bcse/article/view/80286 |
| _version_ | 1811196915375669248 |
|---|---|
| author | B.B. Subudhi G. Ghosh |
| author_facet | B.B. Subudhi G. Ghosh |
| author_sort | B.B. Subudhi |
| collection | DOAJ |
| description | Considering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded compounds 2a-c. Schiff base of sulfanilamide with salicylaldehyde on reaction with thioglycollic acid and chloroacetyl chloride resulted in compound 2d-e. The susceptibility of <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> to the title compounds (300 μg/disc) was investigated and compared to that of nitrofurantoin (300 μg/disc) and ciprofloxacin (25 μg/disc). The title compounds showed good antimicrobial activity.DOI: http://dx.doi.org/10.4314/bcse.v26i3.15 |
| first_indexed | 2024-04-12T01:06:39Z |
| format | Article |
| id | doaj.art-87f66c4456bc4990bb1d9d4161042d2e |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-04-12T01:06:39Z |
| publishDate | 2012-12-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-87f66c4456bc4990bb1d9d4161042d2e2022-12-22T03:54:14ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2012-12-01263455460Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamideB.B. SubudhiG. GhoshConsidering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded compounds 2a-c. Schiff base of sulfanilamide with salicylaldehyde on reaction with thioglycollic acid and chloroacetyl chloride resulted in compound 2d-e. The susceptibility of <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> to the title compounds (300 μg/disc) was investigated and compared to that of nitrofurantoin (300 μg/disc) and ciprofloxacin (25 μg/disc). The title compounds showed good antimicrobial activity.DOI: http://dx.doi.org/10.4314/bcse.v26i3.15http://www.ajol.info/index.php/bcse/article/view/80286Carbonic anhydraseSulfanilamideHeterocyclic compoundsAntimicrobial activity |
| spellingShingle | B.B. Subudhi G. Ghosh Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide Bulletin of the Chemical Society of Ethiopia Carbonic anhydrase Sulfanilamide Heterocyclic compounds Antimicrobial activity |
| title | Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide |
| title_full | Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide |
| title_fullStr | Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide |
| title_full_unstemmed | Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide |
| title_short | Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide |
| title_sort | synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide |
| topic | Carbonic anhydrase Sulfanilamide Heterocyclic compounds Antimicrobial activity |
| url | http://www.ajol.info/index.php/bcse/article/view/80286 |
| work_keys_str_mv | AT bbsubudhi synthesisandantibacterialactivityofsomeheterocyclicderivativesofsulfanilamide AT gghosh synthesisandantibacterialactivityofsomeheterocyclicderivativesofsulfanilamide |