Establishment of a New Zealand White Rabbit Model for Lethal Toxin (LT) Challenge and Efficacy of Monoclonal Antibody 5E11 in the LT-Challenged Rabbit Model

Establishment of a New Zealand White Rabbit Model for Lethal Toxin (LT) Challenge and Efficacy of Monoclonal Antibody 5E11 in the LT-Challenged Rabbit Model

Anthrax caused by Bacillus anthracis is a lethal infectious disease, especially when inhaled, and the mortality rate approaches 100% without treatment. The anthrax antitoxin monoclonal antibody (MAb) 5E11 is a humanized antibody that targets the anthrax protective antigen (PA). The efficacy of 5E11...

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Bibliographic Details
Main Authors: Duanyang Zhang, Weicen Liu, Zhonghua Wen, Bing Li, Shuling Liu, Jianmin Li, Wei Chen
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Toxins
Subjects:
lethal toxin
rabbit model
monoclonal antibody
efficacy of 5E11
Online Access:http://www.mdpi.com/2072-6651/10/7/289

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