Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review
Type 2 Diabetes (T2D) is a polygenic and multi-factorial complex disease. The significant challenge of finding genetic markers that could be used to predict T2D risk remains unresolved. Saudi Arabia is one of several ethnicities with a high prevalence rate of T2D. A large number of studies have been...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Discover STM Publishing Ltd
2018-12-01
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| Series: | Journal of Biochemical and Clinical Genetics |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=14794 |
| _version_ | 1797817504306823168 |
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| author | Khalid Siddiqui Mohthash Musambil Adnan Mahmood Usmani |
| author_facet | Khalid Siddiqui Mohthash Musambil Adnan Mahmood Usmani |
| author_sort | Khalid Siddiqui |
| collection | DOAJ |
| description | Type 2 Diabetes (T2D) is a polygenic and multi-factorial complex disease. The significant challenge of finding genetic markers that could be used to predict T2D risk remains unresolved. Saudi Arabia is one of several ethnicities with a high prevalence rate of T2D. A large number of studies have been performed that explored genetic factors associated with T2D risk. In this work, we conducted a systematic review of published studies on T2D genetic markers in the Saudi population. Multiple databases were employed in the literature review, which focused on studies that either reported the association or non-association of a genetic marker with T2D risk. Using appropriate search terms, we collected, analyzed, and selected 428 articles published between the years of 2000-2018, Of these, 18 articles reported a total of 67 polymorphisms in 46 genes that are strongly linked to T2D in the Saudi population. Most of the relevant studies used genotyping as the primary methodology to identify genetic markers of T2D. Most of these studies were published between the years of 2012-2017. A total of 23 polymorphisms in 17 genes were found to be associated with T2D risk in the Saudi population: KCNJ11, PPARG2, IRS1, VDE, WFS1, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, HNF4A, DUSP9, APOE, HNF1A, SLC30A8, APOC3, SNAP25, and ACE. [JBCGenetics 2018; 1(2.000): 57-65] |
| first_indexed | 2024-03-13T08:54:26Z |
| format | Article |
| id | doaj.art-87f759185f6947d787bdb6c4017d5774 |
| institution | Directory Open Access Journal |
| issn | 1658-807X |
| language | English |
| last_indexed | 2024-03-13T08:54:26Z |
| publishDate | 2018-12-01 |
| publisher | Discover STM Publishing Ltd |
| record_format | Article |
| series | Journal of Biochemical and Clinical Genetics |
| spelling | doaj.art-87f759185f6947d787bdb6c4017d57742023-05-29T05:16:19ZengDiscover STM Publishing LtdJournal of Biochemical and Clinical Genetics1658-807X2018-12-0112576510.24911/JBCGenetics/183-154081122814794Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic ReviewKhalid Siddiqui0Mohthash Musambil1Adnan Mahmood Usmani2Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi ArabiaType 2 Diabetes (T2D) is a polygenic and multi-factorial complex disease. The significant challenge of finding genetic markers that could be used to predict T2D risk remains unresolved. Saudi Arabia is one of several ethnicities with a high prevalence rate of T2D. A large number of studies have been performed that explored genetic factors associated with T2D risk. In this work, we conducted a systematic review of published studies on T2D genetic markers in the Saudi population. Multiple databases were employed in the literature review, which focused on studies that either reported the association or non-association of a genetic marker with T2D risk. Using appropriate search terms, we collected, analyzed, and selected 428 articles published between the years of 2000-2018, Of these, 18 articles reported a total of 67 polymorphisms in 46 genes that are strongly linked to T2D in the Saudi population. Most of the relevant studies used genotyping as the primary methodology to identify genetic markers of T2D. Most of these studies were published between the years of 2012-2017. A total of 23 polymorphisms in 17 genes were found to be associated with T2D risk in the Saudi population: KCNJ11, PPARG2, IRS1, VDE, WFS1, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, HNF4A, DUSP9, APOE, HNF1A, SLC30A8, APOC3, SNAP25, and ACE. [JBCGenetics 2018; 1(2.000): 57-65]http://www.ejmanager.com/fulltextpdf.php?mno=14794type 2 diabetesgeneticssaudi arabia |
| spellingShingle | Khalid Siddiqui Mohthash Musambil Adnan Mahmood Usmani Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review Journal of Biochemical and Clinical Genetics type 2 diabetes genetics saudi arabia |
| title | Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review |
| title_full | Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review |
| title_fullStr | Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review |
| title_full_unstemmed | Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review |
| title_short | Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review |
| title_sort | established type 2 diabetes susceptibility genetic variants in saudi ethnicity a mini systematic review |
| topic | type 2 diabetes genetics saudi arabia |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=14794 |
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