Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study
Background: Sarcopenia is associated with worse outcomes in maintenance hemodialysis (MHD) patients. Differences in criteria and methods used to diagnose sarcopenia, results in a wide range of prevalence. Factors associated with sarcopenia in MHD have not been well-studied. This study aimed to inves...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Interna Publishing
2023-01-01
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| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2239 |
| _version_ | 1827975768365334528 |
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| author | Ria Jauwerissa Maruhum Bonar H. Marbun Pringgodigdo Nugroho Ikhwan Rinaldi Suhardjono Suhardjono Hamzah Shatri Purwita Wijaya Laksmi Irsan Hasan |
| author_facet | Ria Jauwerissa Maruhum Bonar H. Marbun Pringgodigdo Nugroho Ikhwan Rinaldi Suhardjono Suhardjono Hamzah Shatri Purwita Wijaya Laksmi Irsan Hasan |
| author_sort | Ria Jauwerissa |
| collection | DOAJ |
| description | Background: Sarcopenia is associated with worse outcomes in maintenance hemodialysis (MHD) patients. Differences in criteria and methods used to diagnose sarcopenia, results in a wide range of prevalence. Factors associated with sarcopenia in MHD have not been well-studied. This study aimed to investigate the prevalence and factors associated with sarcopenia in the MHD population. Methods: Observational cross-sectional study was done with 96 MHD patients aged ≥18 years old, with dialysis vintage ≥120 days at Cipto Mangunkusumo Hospital March-May 2022. Descriptive, bivariate, and logistic regression analysis were done to find sarcopenia’s prevalence and association with Simplify Creatinine Index (SCI), type 2 diabetes (DM), Interleukin-6 (IL-6), nutritional status, physical activity, and phosphate serum level. Asian Working Group for Sarcopenia (AWGS) 2019 criteria used to diagnose sarcopenia, Hand Grip Strength (HGS) to identify muscle strength, Bioimpedance Spectroscopy (BIS) to calculate muscle mass, and 6-meter walk test to evaluate physical performance. Results: The prevalence of sarcopenia was 54.2%. Factors with a significant association in bivariate analysis were phosphate serum level (p=0.008), SCI (p=0.005) and low physical activity (International Physical Activity Questionnaire) (p-0.006). Logistic regression analysis found higher phosphate serum level and high physical activity protective of sarcopenia (OR 0.677;CI95% 0.493-0.93 and OR 0.313;CI95% 0.130-0.755 respectively). Conclusion: The prevalence of sarcopenia in the MHD population was 54.2%. Phosphate serum level, SCI, and physical activity were significantly correlated with sarcopenia. Both high phosphate level and high physical activity were protective against sarcopenia. |
| first_indexed | 2024-04-09T20:16:38Z |
| format | Article |
| id | doaj.art-87f7d0dcf4134282a0ab75be21319129 |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-04-09T20:16:38Z |
| publishDate | 2023-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-87f7d0dcf4134282a0ab75be213191292023-03-31T07:05:06ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322023-01-01551566Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional StudyRia Jauwerissa0Maruhum Bonar H. Marbun1Pringgodigdo Nugroho2Ikhwan Rinaldi3Suhardjono Suhardjono4Hamzah Shatri5Purwita Wijaya Laksmi6Irsan Hasan7Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Psychosomatic, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaBackground: Sarcopenia is associated with worse outcomes in maintenance hemodialysis (MHD) patients. Differences in criteria and methods used to diagnose sarcopenia, results in a wide range of prevalence. Factors associated with sarcopenia in MHD have not been well-studied. This study aimed to investigate the prevalence and factors associated with sarcopenia in the MHD population. Methods: Observational cross-sectional study was done with 96 MHD patients aged ≥18 years old, with dialysis vintage ≥120 days at Cipto Mangunkusumo Hospital March-May 2022. Descriptive, bivariate, and logistic regression analysis were done to find sarcopenia’s prevalence and association with Simplify Creatinine Index (SCI), type 2 diabetes (DM), Interleukin-6 (IL-6), nutritional status, physical activity, and phosphate serum level. Asian Working Group for Sarcopenia (AWGS) 2019 criteria used to diagnose sarcopenia, Hand Grip Strength (HGS) to identify muscle strength, Bioimpedance Spectroscopy (BIS) to calculate muscle mass, and 6-meter walk test to evaluate physical performance. Results: The prevalence of sarcopenia was 54.2%. Factors with a significant association in bivariate analysis were phosphate serum level (p=0.008), SCI (p=0.005) and low physical activity (International Physical Activity Questionnaire) (p-0.006). Logistic regression analysis found higher phosphate serum level and high physical activity protective of sarcopenia (OR 0.677;CI95% 0.493-0.93 and OR 0.313;CI95% 0.130-0.755 respectively). Conclusion: The prevalence of sarcopenia in the MHD population was 54.2%. Phosphate serum level, SCI, and physical activity were significantly correlated with sarcopenia. Both high phosphate level and high physical activity were protective against sarcopenia.https://actamedindones.org/index.php/ijim/article/view/2239maintenance hemodialysisawgs 2019sarcopenia |
| spellingShingle | Ria Jauwerissa Maruhum Bonar H. Marbun Pringgodigdo Nugroho Ikhwan Rinaldi Suhardjono Suhardjono Hamzah Shatri Purwita Wijaya Laksmi Irsan Hasan Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study Acta Medica Indonesiana maintenance hemodialysis awgs 2019 sarcopenia |
| title | Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study |
| title_full | Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study |
| title_fullStr | Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study |
| title_full_unstemmed | Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study |
| title_short | Factors Associated with Sarcopenia in Maintenance Hemodialysis Patients: A Cross-Sectional Study |
| title_sort | factors associated with sarcopenia in maintenance hemodialysis patients a cross sectional study |
| topic | maintenance hemodialysis awgs 2019 sarcopenia |
| url | https://actamedindones.org/index.php/ijim/article/view/2239 |
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