A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2019-07-01
|
| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ijms.sums.ac.ir/article_44953_42cf3c3a51e545a61c46fd7c32308e6a.pdf |
| _version_ | 1811194417540759552 |
|---|---|
| author | Alireza Sadeghi Maliheh Nejati Azadeh Moghaddas |
| author_facet | Alireza Sadeghi Maliheh Nejati Azadeh Moghaddas |
| author_sort | Alireza Sadeghi |
| collection | DOAJ |
| description | The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbilirubinemia, ascites, hepatosplenomegaly, and anemia. Chemotherapy with a standard regimen containing bortezomib, thalidomide, and dexamethasone was implemented and led to a dramatic response. Liver involvement due to light chain amyloidosis can be the first drastic presentation of MM. It is important to consider infiltrative disorders, like MM and amyloidosis, when patients present non-specific symptoms and impaired liver function tests. Proper and timely diagnosis can directly affect the prognosis of patients. The optimal approach in the standard management of similar cases is still a matter of debate. |
| first_indexed | 2024-04-12T00:26:36Z |
| format | Article |
| id | doaj.art-87f8138bca9f446094f06755d7622c54 |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-04-12T00:26:36Z |
| publishDate | 2019-07-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-87f8138bca9f446094f06755d7622c542022-12-22T03:55:29ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882019-07-0144434234610.30476/ijms.2019.4495344953A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic AmyloidosisAlireza Sadeghi0Maliheh Nejati1Azadeh Moghaddas2Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, IranThe clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbilirubinemia, ascites, hepatosplenomegaly, and anemia. Chemotherapy with a standard regimen containing bortezomib, thalidomide, and dexamethasone was implemented and led to a dramatic response. Liver involvement due to light chain amyloidosis can be the first drastic presentation of MM. It is important to consider infiltrative disorders, like MM and amyloidosis, when patients present non-specific symptoms and impaired liver function tests. Proper and timely diagnosis can directly affect the prognosis of patients. The optimal approach in the standard management of similar cases is still a matter of debate.http://ijms.sums.ac.ir/article_44953_42cf3c3a51e545a61c46fd7c32308e6a.pdfLiver failureMultiple myelomaAmyloidosisHyperbilirubinemia |
| spellingShingle | Alireza Sadeghi Maliheh Nejati Azadeh Moghaddas A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis Iranian Journal of Medical Sciences Liver failure Multiple myeloma Amyloidosis Hyperbilirubinemia |
| title | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis |
| title_full | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis |
| title_fullStr | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis |
| title_full_unstemmed | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis |
| title_short | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis |
| title_sort | rare presentation of multiple myeloma a case report of hepatic amyloidosis |
| topic | Liver failure Multiple myeloma Amyloidosis Hyperbilirubinemia |
| url | http://ijms.sums.ac.ir/article_44953_42cf3c3a51e545a61c46fd7c32308e6a.pdf |
| work_keys_str_mv | AT alirezasadeghi ararepresentationofmultiplemyelomaacasereportofhepaticamyloidosis AT malihehnejati ararepresentationofmultiplemyelomaacasereportofhepaticamyloidosis AT azadehmoghaddas ararepresentationofmultiplemyelomaacasereportofhepaticamyloidosis AT alirezasadeghi rarepresentationofmultiplemyelomaacasereportofhepaticamyloidosis AT malihehnejati rarepresentationofmultiplemyelomaacasereportofhepaticamyloidosis AT azadehmoghaddas rarepresentationofmultiplemyelomaacasereportofhepaticamyloidosis |