Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium
Continuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2012-04-01
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| Series: | Green Processing and Synthesis |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/gps-2011-0002 |
| _version_ | 1818735191202463744 |
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| author | Joshi Ramesh A. Joshi Rohini R. Tibhe Jagdish Nivangune Nayana T. Kulkarni Amol A. |
| author_facet | Joshi Ramesh A. Joshi Rohini R. Tibhe Jagdish Nivangune Nayana T. Kulkarni Amol A. |
| author_sort | Joshi Ramesh A. |
| collection | DOAJ |
| description | Continuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on their suitability. Upon studying the feasibility of continuous flow synthesis of different β-amino crotonates, the synthesis of methyl amino crotonate in the presence of a recyclable and reusable homogeneous acid catalyst has been studied in detail. Tubular reactors were seen to overcome the heat and mass transfer limitations, thereby providing a simple device for even a pilot scale production. A similar approach can be used for the synthesis of other β-amino crotonates. The continuous flow synthesis approach for producing methyl amino crotonate, in the absence of any external solvent, makes it a green process technology. |
| first_indexed | 2024-12-18T00:17:20Z |
| format | Article |
| id | doaj.art-87f89c09b1fb4494949ded3957303dee |
| institution | Directory Open Access Journal |
| issn | 2191-9542 2191-9550 |
| language | English |
| last_indexed | 2024-12-18T00:17:20Z |
| publishDate | 2012-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Green Processing and Synthesis |
| spelling | doaj.art-87f89c09b1fb4494949ded3957303dee2022-12-21T21:27:28ZengDe GruyterGreen Processing and Synthesis2191-95422191-95502012-04-011220521010.1515/gps-2011-0002Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous mediumJoshi Ramesh A.0Joshi Rohini R.1Tibhe Jagdish2Nivangune Nayana T.3Kulkarni Amol A.4Organic Chemistry Division, National Chemical Laboratory, Pune, 411008, IndiaOrganic Chemistry Division, National Chemical Laboratory, Pune, 411008, IndiaChemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, IndiaChemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, IndiaChemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, IndiaContinuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on their suitability. Upon studying the feasibility of continuous flow synthesis of different β-amino crotonates, the synthesis of methyl amino crotonate in the presence of a recyclable and reusable homogeneous acid catalyst has been studied in detail. Tubular reactors were seen to overcome the heat and mass transfer limitations, thereby providing a simple device for even a pilot scale production. A similar approach can be used for the synthesis of other β-amino crotonates. The continuous flow synthesis approach for producing methyl amino crotonate, in the absence of any external solvent, makes it a green process technology.https://doi.org/10.1515/gps-2011-0002β-amino crotonatecontinuous flow synthesishantzsch synthesismicroreactor |
| spellingShingle | Joshi Ramesh A. Joshi Rohini R. Tibhe Jagdish Nivangune Nayana T. Kulkarni Amol A. Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium Green Processing and Synthesis β-amino crotonate continuous flow synthesis hantzsch synthesis microreactor |
| title | Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium |
| title_full | Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium |
| title_fullStr | Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium |
| title_full_unstemmed | Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium |
| title_short | Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium |
| title_sort | continuous flow synthesis of β amino α β unsaturated esters in aqueous medium |
| topic | β-amino crotonate continuous flow synthesis hantzsch synthesis microreactor |
| url | https://doi.org/10.1515/gps-2011-0002 |
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