Aspirin in COVID-19: Pros and Cons
Since its emergence, the COVID-19 pandemic has been ravaging the medical and economic sectors even with the significant vaccination advances. In severe presentations, the disease of SARS-CoV-2 can manifest with life-threatening thromboembolic and multi-organ repercussions provoking notable morbidity...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.849628/full |
| _version_ | 1819104537574637568 |
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| author | Rana Zareef Marwa Diab Tala Al Saleh Adham Makarem Nour K. Younis Fadi Bitar Fadi Bitar Fadi Bitar Mariam Arabi Mariam Arabi Mariam Arabi |
| author_facet | Rana Zareef Marwa Diab Tala Al Saleh Adham Makarem Nour K. Younis Fadi Bitar Fadi Bitar Fadi Bitar Mariam Arabi Mariam Arabi Mariam Arabi |
| author_sort | Rana Zareef |
| collection | DOAJ |
| description | Since its emergence, the COVID-19 pandemic has been ravaging the medical and economic sectors even with the significant vaccination advances. In severe presentations, the disease of SARS-CoV-2 can manifest with life-threatening thromboembolic and multi-organ repercussions provoking notable morbidity and mortality. The pathogenesis of such burdensome forms has been under extensive investigation and is attributed to a state of immune dysfunction and hyperinflammation. In light of these extraordinary circumstances, research efforts have focused on investigating and repurposing previously available agents that target the inflammatory and hematological cascades. Aspirin, due to its well-known properties and multiple molecular targets, and ought to its extensive clinical use, has been perceived as a potential therapeutic agent for COVID-19. Aspirin acts at multiple cellular targets to achieve its anti-inflammatory and anti-platelet effects. Although initial promising clinical data describing aspirin role in COVID-19 has appeared, evidence supporting its use remains fragile and premature. This review explores the notion of repurposing aspirin in COVID-19 infection. It delves into aspirin as a molecule, along with its pharmacology and clinical applications. It also reviews the current high-quality clinical evidence highlighting the role of aspirin in SARS-CoV-2 infection. |
| first_indexed | 2024-12-22T02:07:56Z |
| format | Article |
| id | doaj.art-87f90079f615462e8a567c55a2678db4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T02:07:56Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-87f90079f615462e8a567c55a2678db42022-12-21T18:42:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.849628849628Aspirin in COVID-19: Pros and ConsRana Zareef0Marwa Diab1Tala Al Saleh2Adham Makarem3Nour K. Younis4Fadi Bitar5Fadi Bitar6Fadi Bitar7Mariam Arabi8Mariam Arabi9Mariam Arabi10Pediatric and Adolescent Medicine Department, American University of Beirut Medical Center, Beirut, LebanonPediatric and Adolescent Medicine Department, American University of Beirut Medical Center, Beirut, LebanonFaculty of Medicine, American University of Beirut Medical Center, Beirut, LebanonFaculty of Medicine, American University of Beirut Medical Center, Beirut, LebanonBrigham and Women’s Hospital-Harvard Medical School, Boston, MA, United StatesPediatric and Adolescent Medicine Department, American University of Beirut Medical Center, Beirut, LebanonFaculty of Medicine, American University of Beirut Medical Center, Beirut, LebanonPediatric Department, Division of Pediatric Cardiology, American University of Beirut Medical Center, Beirut, LebanonPediatric and Adolescent Medicine Department, American University of Beirut Medical Center, Beirut, LebanonFaculty of Medicine, American University of Beirut Medical Center, Beirut, LebanonPediatric Department, Division of Pediatric Cardiology, American University of Beirut Medical Center, Beirut, LebanonSince its emergence, the COVID-19 pandemic has been ravaging the medical and economic sectors even with the significant vaccination advances. In severe presentations, the disease of SARS-CoV-2 can manifest with life-threatening thromboembolic and multi-organ repercussions provoking notable morbidity and mortality. The pathogenesis of such burdensome forms has been under extensive investigation and is attributed to a state of immune dysfunction and hyperinflammation. In light of these extraordinary circumstances, research efforts have focused on investigating and repurposing previously available agents that target the inflammatory and hematological cascades. Aspirin, due to its well-known properties and multiple molecular targets, and ought to its extensive clinical use, has been perceived as a potential therapeutic agent for COVID-19. Aspirin acts at multiple cellular targets to achieve its anti-inflammatory and anti-platelet effects. Although initial promising clinical data describing aspirin role in COVID-19 has appeared, evidence supporting its use remains fragile and premature. This review explores the notion of repurposing aspirin in COVID-19 infection. It delves into aspirin as a molecule, along with its pharmacology and clinical applications. It also reviews the current high-quality clinical evidence highlighting the role of aspirin in SARS-CoV-2 infection.https://www.frontiersin.org/articles/10.3389/fphar.2022.849628/fullCOVID-19SARS-CoV-2coronavirusaspirinsalicylic acid |
| spellingShingle | Rana Zareef Marwa Diab Tala Al Saleh Adham Makarem Nour K. Younis Fadi Bitar Fadi Bitar Fadi Bitar Mariam Arabi Mariam Arabi Mariam Arabi Aspirin in COVID-19: Pros and Cons Frontiers in Pharmacology COVID-19 SARS-CoV-2 coronavirus aspirin salicylic acid |
| title | Aspirin in COVID-19: Pros and Cons |
| title_full | Aspirin in COVID-19: Pros and Cons |
| title_fullStr | Aspirin in COVID-19: Pros and Cons |
| title_full_unstemmed | Aspirin in COVID-19: Pros and Cons |
| title_short | Aspirin in COVID-19: Pros and Cons |
| title_sort | aspirin in covid 19 pros and cons |
| topic | COVID-19 SARS-CoV-2 coronavirus aspirin salicylic acid |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.849628/full |
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