Simultaneous analysis of dapagliflozin and its three related impurities by stability-indicating UPLC method and in vitro toxicity evaluation

Simultaneous analysis of dapagliflozin and its three related impurities by stability-indicating UPLC method and in vitro toxicity evaluation

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A new stability- indicating analytical method by UPLC was developed for the simultaneous determination of dapagliflozin and three of its synthesis impurities. A Waters® Acquity UPLC H- Class model was used for method development and validation. The separation was achieved in a Zorbax phenyl column (...

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Bibliographic Details
Main Authors: Lívia Bueno, Joanna Wittckind Manoel, Mariana Koetz, Amélia Teresinha Henriques, Martin Steppe, Elfrides Eva Scherman Schapoval
Format: Article
Language:English
Published: Universidade Federal do Rio Grande do Sul 2023-01-01
Series:Drug Analytical Research
Subjects:
dapagliflozin
uplc
validation
drug impurities
toxicity assay
Online Access:https://www.seer.ufrgs.br/index.php/dar/article/view/128661

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