Matrilin-2 within a three-dimensional lysine-modified chitosan porous scaffold enhances Schwann cell migration and axonal outgrowth for peripheral nerve regeneration

Matrilin-2 within a three-dimensional lysine-modified chitosan porous scaffold enhances Schwann cell migration and axonal outgrowth for peripheral nerve regeneration

Background: Matrilin-2 is a key extracellular matrix protein involved in peripheral nerve regeneration. We sought to develop a biomimetic scaffold to enhance peripheral nerve regeneration by incorporating matrilin-2 within a chitosan-derived porous scaffold. We hypothesized that the use of such a no...

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Bibliographic Details
Main Authors: Neill Y. Li, Brandon Vorrius, Jonathan Ge, Zhen Qiao, Shuang Zhu, Julia Katarincic, Qian Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
nerve regeneration
scaffold
chitosan
matrilin-2
schwann cell
axon
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1142610/full

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