Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases
BackgroundIn recent years, marine-based functional foods and combination therapy are receiving greater recognition for their roles in healthy lifestyle applications and are being investigated as viable and effective strategies for disease treatment or prevention.Aim of the reviewThis review article...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1047026/full |
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| author | Belgheis Ebrahimi Saeid Baroutian Jinyao Li Baohong Zhang Tianlei Ying Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu |
| author_facet | Belgheis Ebrahimi Saeid Baroutian Jinyao Li Baohong Zhang Tianlei Ying Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu |
| author_sort | Belgheis Ebrahimi |
| collection | DOAJ |
| description | BackgroundIn recent years, marine-based functional foods and combination therapy are receiving greater recognition for their roles in healthy lifestyle applications and are being investigated as viable and effective strategies for disease treatment or prevention.Aim of the reviewThis review article presents and discusses the relevant scientific publications that have studied the synergistic and additive effects of natural marine bioactive compounds and extract combinations with anti-obesity, anti-inflammatory, antioxidant, and chemopreventive activities in the last two decades. The paper presents the mechanism of action and health benefits of developed combinations and discusses the limitation of the studies. Furthermore, it recommends alternatives and directions for future studies. Finally, it highlights the factors for developing novel combinations of marine bioactive compounds.Key scientific concepts of reviewCombination of marine bioactive compounds or extracts affords synergistic or additive effects by multiple means, such as multi-target effects, enhancing the bioavailability, boosting the bioactivity, and neutralizing adverse effects of compounds in the mixture. For the development of marine-based combinations, there are key points for consideration and issues to address: knowledge of the mechanism of action of individual compounds and their combinations, optimum ratio and dosing of compounds, and experimental models must all be taken into account. Strategies to increase the number and diversity of marine combinations, and further development of marine-based functional foods, are available. However, only a small number of natural marine bioactive combinations have been assessed, and most research has been focused on fish oil and carotenoid synergy. Therefore, more research and resources should be spent on developing novel marine bioactive combinations as functional foods and nutraceuticals. |
| first_indexed | 2024-04-10T23:30:46Z |
| format | Article |
| id | doaj.art-87ffa513c130481c9fd6bd5558e3f0b8 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T23:30:46Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-87ffa513c130481c9fd6bd5558e3f0b82023-01-12T06:31:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10470261047026Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseasesBelgheis Ebrahimi0Saeid Baroutian1Jinyao Li2Baohong Zhang3Tianlei Ying4Jun Lu5Jun Lu6Jun Lu7Jun Lu8Jun Lu9Jun Lu10Jun Lu11School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New ZealandDepartment of Chemical and Materials Engineering, University of Auckland, Auckland, New ZealandXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Xinjiang, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, Shanghai, ChinaSchool of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New ZealandAuckland Bioengineering Institute, University of Auckland, Auckland, New ZealandInstitute of Biomedical Technology, Auckland University of Technology, Auckland, New ZealandMaurice Wilkins Centre for Molecular Discovery, Auckland, New ZealandCollege of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, China0College of Food Engineering and Nutrition Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China1College of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, ChinaBackgroundIn recent years, marine-based functional foods and combination therapy are receiving greater recognition for their roles in healthy lifestyle applications and are being investigated as viable and effective strategies for disease treatment or prevention.Aim of the reviewThis review article presents and discusses the relevant scientific publications that have studied the synergistic and additive effects of natural marine bioactive compounds and extract combinations with anti-obesity, anti-inflammatory, antioxidant, and chemopreventive activities in the last two decades. The paper presents the mechanism of action and health benefits of developed combinations and discusses the limitation of the studies. Furthermore, it recommends alternatives and directions for future studies. Finally, it highlights the factors for developing novel combinations of marine bioactive compounds.Key scientific concepts of reviewCombination of marine bioactive compounds or extracts affords synergistic or additive effects by multiple means, such as multi-target effects, enhancing the bioavailability, boosting the bioactivity, and neutralizing adverse effects of compounds in the mixture. For the development of marine-based combinations, there are key points for consideration and issues to address: knowledge of the mechanism of action of individual compounds and their combinations, optimum ratio and dosing of compounds, and experimental models must all be taken into account. Strategies to increase the number and diversity of marine combinations, and further development of marine-based functional foods, are available. However, only a small number of natural marine bioactive combinations have been assessed, and most research has been focused on fish oil and carotenoid synergy. Therefore, more research and resources should be spent on developing novel marine bioactive combinations as functional foods and nutraceuticals.https://www.frontiersin.org/articles/10.3389/fnut.2022.1047026/fullmarine bioactivesmarine nutraceutical combinationantioxidantanti-inflammatoryanticarcinogenicanti-obesity |
| spellingShingle | Belgheis Ebrahimi Saeid Baroutian Jinyao Li Baohong Zhang Tianlei Ying Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Jun Lu Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases Frontiers in Nutrition marine bioactives marine nutraceutical combination antioxidant anti-inflammatory anticarcinogenic anti-obesity |
| title | Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases |
| title_full | Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases |
| title_fullStr | Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases |
| title_full_unstemmed | Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases |
| title_short | Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases |
| title_sort | combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases |
| topic | marine bioactives marine nutraceutical combination antioxidant anti-inflammatory anticarcinogenic anti-obesity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1047026/full |
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