Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin
Background S. setigera is widely used in traditional medicine throughout the world. Ethnobotanical surveys have revealed its use to handle diabetes. This present research investigated the antioxidant potential and improvement activities of S. setigera Delile on insulin resistance in type 2 diabetic...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-06-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258231185460 |
| _version_ | 1827921277969498112 |
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| author | Zacharie Tchoubou Benoît Bargui Koubala Dieudonné Ndjonka |
| author_facet | Zacharie Tchoubou Benoît Bargui Koubala Dieudonné Ndjonka |
| author_sort | Zacharie Tchoubou |
| collection | DOAJ |
| description | Background S. setigera is widely used in traditional medicine throughout the world. Ethnobotanical surveys have revealed its use to handle diabetes. This present research investigated the antioxidant potential and improvement activities of S. setigera Delile on insulin resistance in type 2 diabetic rats. Methods Male rats fed high-fat diet for 6 weeks followed by a single-dose intraperitoneal injection of streptozotocin (35 mg/kg) induced hyperglycemia. 72 hours after injection of streptozotocin, diabetic rats received treatment for 21 days. Fasting blood glucose was measured. Serum biochemical and hepatic biomarkers were evaluated. A hepatic histological study was performed. Oxidative stress biomarkers were assessed in liver. Results Doses of 200 and 400 mg/kg reduced the blood glucose with the reduction index of 53.75 and 62.1%, respectively. There was also good improvement in lipid profile and insulin. The dose of 400 mg/kg better reduced subcutaneous fat mass with a difference in reduction index (1.5 to 5.8%). The extract resulted in a decrease in malondialdehyde levels and an increase in catalase activities. The extract showed significant inhibitory potential towards α-amylase 18.78% to 55.91% and α-glucosidase 23.91% to 67.76%. Conclusion S. setigera extract could thus reverse insulin resistance and oxidative stress in type 2 diabetic rats induced. |
| first_indexed | 2024-03-13T04:23:57Z |
| format | Article |
| id | doaj.art-880082982c9d4164a008e3e627585a7c |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-03-13T04:23:57Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-880082982c9d4164a008e3e627585a7c2023-06-20T08:03:19ZengSAGE PublishingDose-Response1559-32582023-06-012110.1177/15593258231185460Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of StreptozotocinZacharie TchoubouBenoît Bargui KoubalaDieudonné NdjonkaBackground S. setigera is widely used in traditional medicine throughout the world. Ethnobotanical surveys have revealed its use to handle diabetes. This present research investigated the antioxidant potential and improvement activities of S. setigera Delile on insulin resistance in type 2 diabetic rats. Methods Male rats fed high-fat diet for 6 weeks followed by a single-dose intraperitoneal injection of streptozotocin (35 mg/kg) induced hyperglycemia. 72 hours after injection of streptozotocin, diabetic rats received treatment for 21 days. Fasting blood glucose was measured. Serum biochemical and hepatic biomarkers were evaluated. A hepatic histological study was performed. Oxidative stress biomarkers were assessed in liver. Results Doses of 200 and 400 mg/kg reduced the blood glucose with the reduction index of 53.75 and 62.1%, respectively. There was also good improvement in lipid profile and insulin. The dose of 400 mg/kg better reduced subcutaneous fat mass with a difference in reduction index (1.5 to 5.8%). The extract resulted in a decrease in malondialdehyde levels and an increase in catalase activities. The extract showed significant inhibitory potential towards α-amylase 18.78% to 55.91% and α-glucosidase 23.91% to 67.76%. Conclusion S. setigera extract could thus reverse insulin resistance and oxidative stress in type 2 diabetic rats induced.https://doi.org/10.1177/15593258231185460 |
| spellingShingle | Zacharie Tchoubou Benoît Bargui Koubala Dieudonné Ndjonka Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin Dose-Response |
| title | Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin |
| title_full | Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin |
| title_fullStr | Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin |
| title_full_unstemmed | Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin |
| title_short | Antioxidant Potential and Improvement Activities of Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin |
| title_sort | antioxidant potential and improvement activities of delile on insulin resistance in type 2 diabetic rats induced by high fat diet and low dose of streptozotocin |
| url | https://doi.org/10.1177/15593258231185460 |
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