The gut microbiome: A line of defense against tuberculosis development
The tuberculosis (TB) burden remains a significant global public health concern, especially in less developed countries. While pulmonary tuberculosis (PTB) is the most common form of the disease, extrapulmonary tuberculosis, particularly intestinal TB (ITB), which is mostly secondary to PTB, is also...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1149679/full |
| _version_ | 1827965136524017664 |
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| author | Ziqi Yu Xiang Shen Aiyao Wang Chong Hu Jianyong Chen |
| author_facet | Ziqi Yu Xiang Shen Aiyao Wang Chong Hu Jianyong Chen |
| author_sort | Ziqi Yu |
| collection | DOAJ |
| description | The tuberculosis (TB) burden remains a significant global public health concern, especially in less developed countries. While pulmonary tuberculosis (PTB) is the most common form of the disease, extrapulmonary tuberculosis, particularly intestinal TB (ITB), which is mostly secondary to PTB, is also a significant issue. With the development of sequencing technologies, recent studies have investigated the potential role of the gut microbiome in TB development. In this review, we summarized studies investigating the gut microbiome in both PTB and ITB patients (secondary to PTB) compared with healthy controls. Both PTB and ITB patients show reduced gut microbiome diversity characterized by reduced Firmicutes and elevated opportunistic pathogens colonization; Bacteroides and Prevotella were reported with opposite alteration in PTB and ITB patients. The alteration reported in TB patients may lead to a disequilibrium in metabolites such as short-chain fatty acid (SCFA) production, which may recast the lung microbiome and immunity via the “gut-lung axis”. These findings may also shed light on the colonization of Mycobacterium tuberculosis in the gastrointestinal tract and the development of ITB in PTB patients. The findings highlight the crucial role of the gut microbiome in TB, particularly in ITB development, and suggest that probiotics and postbiotics might be useful supplements in shaping a balanced gut microbiome during TB treatment. |
| first_indexed | 2024-04-09T17:27:13Z |
| format | Article |
| id | doaj.art-8800ced73cfc488b85cfebdd412cc402 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T17:27:13Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-8800ced73cfc488b85cfebdd412cc4022023-04-18T10:11:08ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-04-011310.3389/fcimb.2023.11496791149679The gut microbiome: A line of defense against tuberculosis developmentZiqi Yu0Xiang Shen1Aiyao Wang2Chong Hu3Jianyong Chen4Munich Medical Research School, Ludwig Maximilian University of Munich (LMU), Munich, GermanyMunich Medical Research School, Ludwig Maximilian University of Munich (LMU), Munich, GermanyDepartment of Gastroenterology and Hepatology, the First Affiliated Hospital of Nanchang Medical College, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology and Hepatology, the First Affiliated Hospital of Nanchang Medical College, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology and Hepatology, the First Affiliated Hospital of Nanchang Medical College, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, ChinaThe tuberculosis (TB) burden remains a significant global public health concern, especially in less developed countries. While pulmonary tuberculosis (PTB) is the most common form of the disease, extrapulmonary tuberculosis, particularly intestinal TB (ITB), which is mostly secondary to PTB, is also a significant issue. With the development of sequencing technologies, recent studies have investigated the potential role of the gut microbiome in TB development. In this review, we summarized studies investigating the gut microbiome in both PTB and ITB patients (secondary to PTB) compared with healthy controls. Both PTB and ITB patients show reduced gut microbiome diversity characterized by reduced Firmicutes and elevated opportunistic pathogens colonization; Bacteroides and Prevotella were reported with opposite alteration in PTB and ITB patients. The alteration reported in TB patients may lead to a disequilibrium in metabolites such as short-chain fatty acid (SCFA) production, which may recast the lung microbiome and immunity via the “gut-lung axis”. These findings may also shed light on the colonization of Mycobacterium tuberculosis in the gastrointestinal tract and the development of ITB in PTB patients. The findings highlight the crucial role of the gut microbiome in TB, particularly in ITB development, and suggest that probiotics and postbiotics might be useful supplements in shaping a balanced gut microbiome during TB treatment.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1149679/fullgut microbiomeMycobacterium tuberculosisFirmicutesBacteroidetesshort-chain fatty acidstuberculosis |
| spellingShingle | Ziqi Yu Xiang Shen Aiyao Wang Chong Hu Jianyong Chen The gut microbiome: A line of defense against tuberculosis development Frontiers in Cellular and Infection Microbiology gut microbiome Mycobacterium tuberculosis Firmicutes Bacteroidetes short-chain fatty acids tuberculosis |
| title | The gut microbiome: A line of defense against tuberculosis development |
| title_full | The gut microbiome: A line of defense against tuberculosis development |
| title_fullStr | The gut microbiome: A line of defense against tuberculosis development |
| title_full_unstemmed | The gut microbiome: A line of defense against tuberculosis development |
| title_short | The gut microbiome: A line of defense against tuberculosis development |
| title_sort | gut microbiome a line of defense against tuberculosis development |
| topic | gut microbiome Mycobacterium tuberculosis Firmicutes Bacteroidetes short-chain fatty acids tuberculosis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1149679/full |
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