Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy
Abstract Background and Aim To assess the efficacy and safety of 7‐day Helicobacter pylori rescue treatment consisting of a vonoprazan (VPZ), metronidazole (MNZ), and sitafloxacin (STFX) regimen (VPZ‐MNZ‐STFX therapy) in patients with penicillin allergy. Methods This was a registered prospective int...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-02-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12492 |
| _version_ | 1818948715178622976 |
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| author | Soichiro Sue Tomohiko Sasaki Hiroaki Kaneko Kuniyasu Irie Masaaki Kondo Shin Maeda |
| author_facet | Soichiro Sue Tomohiko Sasaki Hiroaki Kaneko Kuniyasu Irie Masaaki Kondo Shin Maeda |
| author_sort | Soichiro Sue |
| collection | DOAJ |
| description | Abstract Background and Aim To assess the efficacy and safety of 7‐day Helicobacter pylori rescue treatment consisting of a vonoprazan (VPZ), metronidazole (MNZ), and sitafloxacin (STFX) regimen (VPZ‐MNZ‐STFX therapy) in patients with penicillin allergy. Methods This was a registered prospective intervention study. Patients with penicillin allergy who were diagnosed with H. pylori infection and had a history of H. pylori eradication were eligible for inclusion. Seventeen patients were prospectively treated with VPZ 20 mg bid, MNZ 250 mg bid, and STFX 100 mg bid for 7 days. Safety was evaluated using a questionnaire on adverse effects. Results The eradication rate of 7‐day VPZ‐MNZ‐SFTX therapy was 88.2% (95% confidence interval: 63.6–98.5%; n = 17) in both intention‐to‐treat and per‐protocol analyses. On the questionnaire, 25% of patients reported experiencing diarrhea, with a score of 2 or 3. All patients undergoing VPZ‐MNZ‐STFX therapy completed 100% of their medication course. Conclusion Rescue H. pylori eradication with VPZ‐MNZ‐STFX therapy is effective and well tolerated in patients with penicillin allergy (UMIN000016335, jRCTs031180133). |
| first_indexed | 2024-12-20T08:51:12Z |
| format | Article |
| id | doaj.art-88022883447a43819c5abd32292284a6 |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-12-20T08:51:12Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-88022883447a43819c5abd32292284a62022-12-21T19:46:07ZengWileyJGH Open2397-90702021-02-015230731110.1002/jgh3.12492Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergySoichiro Sue0Tomohiko Sasaki1Hiroaki Kaneko2Kuniyasu Irie3Masaaki Kondo4Shin Maeda5Department of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama JapanAbstract Background and Aim To assess the efficacy and safety of 7‐day Helicobacter pylori rescue treatment consisting of a vonoprazan (VPZ), metronidazole (MNZ), and sitafloxacin (STFX) regimen (VPZ‐MNZ‐STFX therapy) in patients with penicillin allergy. Methods This was a registered prospective intervention study. Patients with penicillin allergy who were diagnosed with H. pylori infection and had a history of H. pylori eradication were eligible for inclusion. Seventeen patients were prospectively treated with VPZ 20 mg bid, MNZ 250 mg bid, and STFX 100 mg bid for 7 days. Safety was evaluated using a questionnaire on adverse effects. Results The eradication rate of 7‐day VPZ‐MNZ‐SFTX therapy was 88.2% (95% confidence interval: 63.6–98.5%; n = 17) in both intention‐to‐treat and per‐protocol analyses. On the questionnaire, 25% of patients reported experiencing diarrhea, with a score of 2 or 3. All patients undergoing VPZ‐MNZ‐STFX therapy completed 100% of their medication course. Conclusion Rescue H. pylori eradication with VPZ‐MNZ‐STFX therapy is effective and well tolerated in patients with penicillin allergy (UMIN000016335, jRCTs031180133).https://doi.org/10.1002/jgh3.12492Helicobacter pylorihypersensitivitymetronidazolesitafloxacinvonoprazan |
| spellingShingle | Soichiro Sue Tomohiko Sasaki Hiroaki Kaneko Kuniyasu Irie Masaaki Kondo Shin Maeda Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy JGH Open Helicobacter pylori hypersensitivity metronidazole sitafloxacin vonoprazan |
| title | Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy |
| title_full | Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy |
| title_fullStr | Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy |
| title_full_unstemmed | Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy |
| title_short | Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy |
| title_sort | helicobacter pylori rescue treatment with vonoprazan metronidazole and sitafloxacin in the presence of penicillin allergy |
| topic | Helicobacter pylori hypersensitivity metronidazole sitafloxacin vonoprazan |
| url | https://doi.org/10.1002/jgh3.12492 |
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