Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions
The SET and MYND domain-containing (SMYD) family of lysine methyltransferases are essential in several mammalian developmental pathways. Although predominantly expressed in the heart, the role of SMYD2 in heart development has yet to be fully elucidated and has even been shown to be dispensable in a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/7/2/63 |
| _version_ | 1827717075075858432 |
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| author | Dillon K. Jarrell Kelly N. Hassell Debbie C. Crans Shari Lanning Mark A. Brown |
| author_facet | Dillon K. Jarrell Kelly N. Hassell Debbie C. Crans Shari Lanning Mark A. Brown |
| author_sort | Dillon K. Jarrell |
| collection | DOAJ |
| description | The SET and MYND domain-containing (SMYD) family of lysine methyltransferases are essential in several mammalian developmental pathways. Although predominantly expressed in the heart, the role of SMYD2 in heart development has yet to be fully elucidated and has even been shown to be dispensable in a murine Nkx2-5-associated conditional knockout. Additionally, SMYD2 was recently shown to be necessary not only for lymphocyte development but also for the viability of hematopoietic leukemias. Based on the broad expression pattern of SMYD2 in mammalian tissues, it is likely that it plays pivotal roles in a host of additional normal and pathological processes. In this brief review, we consider what is currently known about the normal and pathogenic functions of SMYD2 and propose specific future directions for characterizing its role in embryogenesis. |
| first_indexed | 2024-03-10T19:53:41Z |
| format | Article |
| id | doaj.art-8803c21b6c864e8cb7c224f7ad882797 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T19:53:41Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-8803c21b6c864e8cb7c224f7ad8827972023-11-20T00:10:28ZengMDPI AGVeterinary Sciences2306-73812020-05-01726310.3390/vetsci7020063Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future DirectionsDillon K. Jarrell0Kelly N. Hassell1Debbie C. Crans2Shari Lanning3Mark A. Brown4Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80523, USACell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USACell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USADepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USACell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USAThe SET and MYND domain-containing (SMYD) family of lysine methyltransferases are essential in several mammalian developmental pathways. Although predominantly expressed in the heart, the role of SMYD2 in heart development has yet to be fully elucidated and has even been shown to be dispensable in a murine Nkx2-5-associated conditional knockout. Additionally, SMYD2 was recently shown to be necessary not only for lymphocyte development but also for the viability of hematopoietic leukemias. Based on the broad expression pattern of SMYD2 in mammalian tissues, it is likely that it plays pivotal roles in a host of additional normal and pathological processes. In this brief review, we consider what is currently known about the normal and pathogenic functions of SMYD2 and propose specific future directions for characterizing its role in embryogenesis.https://www.mdpi.com/2306-7381/7/2/63epigeneticscancerhematopoiesisleukemiahistone methylationvomeronasal organ |
| spellingShingle | Dillon K. Jarrell Kelly N. Hassell Debbie C. Crans Shari Lanning Mark A. Brown Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions Veterinary Sciences epigenetics cancer hematopoiesis leukemia histone methylation vomeronasal organ |
| title | Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions |
| title_full | Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions |
| title_fullStr | Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions |
| title_full_unstemmed | Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions |
| title_short | Characterizing the Role of SMYD2 in Mammalian Embryogenesis—Future Directions |
| title_sort | characterizing the role of smyd2 in mammalian embryogenesis future directions |
| topic | epigenetics cancer hematopoiesis leukemia histone methylation vomeronasal organ |
| url | https://www.mdpi.com/2306-7381/7/2/63 |
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