Transcriptome profiling reveals the anti-diabetic molecular mechanism of Cyclocarya paliurus polysaccharides

Transcriptome profiling reveals the anti-diabetic molecular mechanism of Cyclocarya paliurus polysaccharides

Cyclocarya paliurus polysaccharides have been reported to prevent diabetes, but the underlying mechanisms are unclear. This current study aimed to reveal the possible underlying anti-diabetic mechanisms of CPP based on transcriptome profiling. Our experimental results demonstrated CPP could protect...

Full description

Bibliographic Details
Main Authors:	Jing Li, Mei Luo, Zhen Luo, An-Yuan Guo, Xiangliang Yang, Minghua Hu, Qiong Zhang, Yanhong Zhu
Format:	Article
Language:	English
Published:	Elsevier 2019-04-01
Series:	Journal of Functional Foods
Subjects:	Diabetes Cyclocarya paliurus polysaccharides Transcriptome profiling Pancreas islet Hepatic steatosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464618306789

Similar Items

Immunomodulatory activities of sulfated Cyclocarya paliurus polysaccharides with different degrees of substitution on mouse spleen lymphocytes
by: Yue Yu, et al.
Published: (2020-01-01)

Transcriptome analysis associated with polysaccharide synthesis and their antioxidant activity in Cyclocarya paliurus leaves of different developmental stages
by: Weida Lin, et al.
Published: (2021-06-01)

Integrated Metabolomic and Transcriptomic Analysis of the Flavonoid Accumulation in the Leaves of Cyclocarya paliurus at Different Altitudes
by: Zhaokui Du, et al.
Published: (2022-02-01)

Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways
by: Yue Yu, et al.
Published: (2024-01-01)

Etiology of Cyclocarya paliurus Anthracnose in Jiangsu Province, China
by: Xiang-rong Zheng, et al.
Published: (2021-01-01)

Apoptosis of colon cancer CT-26 cells induced polysaccharide from Cyclocarya paliurus and its phosphorylated derivative via intrinsic mitochondrial passway
by: Liuming Xie, et al.
Published: (2023-09-01)

Investigating the Molecular Mechanism of Aqueous Extract of Cyclocarya paliurus on Ameliorating Diabetes by Transcriptome Profiling
by: Jing Li, et al.
Published: (2018-08-01)

Amino acids profiling and transcriptomic data integration demonstrates the dynamic regulation of amino acids synthesis in the leaves of Cyclocarya paliurus
by: Zhaokui Du, et al.
Published: (2022-07-01)

Variation in growth, photosynthesis and water-soluble polysaccharide of Cyclocarya paliurus under different light regimes
by: Yang W, et al.
Published: (2017-04-01)

Metabolome and Whole-Transcriptome Analyses Reveal the Molecular Mechanisms Underlying Hypoglycemic Nutrient Metabolites Biosynthesis in Cyclocarya paliurus Leaves During Different Harvest Stages
by: Xuehai Zheng, et al.
Published: (2022-02-01)

Development of Microsatellite Loci for <i>Cyclocarya paliurus</i> (Juglandaceae), A Monotypic Species in Subtropical China
by: Deng-Mei Fan, et al.
Published: (2013-06-01)

Comparative analysis of the complete chloroplast genome between tetraploidy and diploidy of Cyclocarya paliurus (Batal.) Iljinskaja
by: Yinquan Qu, et al.
Published: (2021-09-01)

Anti-Hyperglycemic Effects of Refined Fractions from <i>Cyclocarya paliurus</i> Leaves on Streptozotocin-Induced Diabetic Mice
by: Zheling Feng, et al.
Published: (2021-11-01)

The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves
by: Cencen Liu, et al.
Published: (2022-09-01)

Cyclocarya paliurus Reprograms the Flavonoid Biosynthesis Pathway Against Colletotrichum fructicola
by: Xiang-Rong Zheng, et al.
Published: (2022-06-01)

Combined Analysis of the Metabolome and Transcriptome Identified Candidate Genes Involved in Phenolic Acid Biosynthesis in the Leaves of <i>Cyclocarya paliurus</i>
by: Weida Lin, et al.
Published: (2020-02-01)

Effect of Different Protein Removal Methods on the Structure and Antioxidant Activity of the Cyclocarya paliurus Polysaccharides
by: Sichen HE, et al.
Published: (2023-08-01)

Phytochemical content and antioxidant activity in aqueous extracts of Cyclocarya paliurus leaves collected from different populations
by: Mingming Zhou, et al.
Published: (2019-02-01)

The phytochemicals and health benefits of Cyclocarya paliurus (Batalin) Iljinskaja
by: Yingbin Shen, et al.
Published: (2023-04-01)

Structure and in vitro antioxidant and immunomodulatory activity of a glucan from the leaves of Cyclocarya paliurus
by: Sichen He, et al.
Published: (2024-02-01)

Polysaccharides from Cyclocarya paliurus: Chemical composition and lipid-lowering effect on rats challenged with high-fat diet
by: Wen-Bing Hu, et al.
Published: (2017-09-01)

Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from Cyclocarya paliurus (Batal) Iljinskaja Leaves
by: Yang Liu, et al.
Published: (2018-09-01)

Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation
by: Li-Hua Zhu, et al.
Published: (2022-07-01)

Whole-genome Duplication Reshaped Adaptive Evolution in A Relict Plant Species, Cyclocarya paliurus
by: Yinquan Qu, et al.
Published: (2023-06-01)

Association Analysis Between Genotype and Environment: Differentiation Between Cyclocarya paliurus Resources That Accumulate Triterpenoids
by: Caowen Sun, et al.
Published: (2022-08-01)

An Integrative Analysis of Metabolome and Transcriptome Reveals the Molecular Regulatory Mechanism of the Accumulation of Flavonoid Glycosides in Different <i>Cyclocarya paliurus</i> Ploidies
by: Yanhao Yu, et al.
Published: (2023-04-01)

Cyclocarya paliurus Triterpenoids Improve Diabetes-Induced Hepatic Inflammation via the Rho-Kinase-Dependent Pathway
by: Cuihua Jiang, et al.
Published: (2019-07-01)

Transcriptomic and Non-Targeted Metabolomic Analyses Reveal Changes in Metabolic Networks during Leaf Coloration in <i>Cyclocarya paliurus</i> (Batalin) Iljinsk
by: Caowen Sun, et al.
Published: (2023-09-01)

Cyclocarya paliurus leaves alleviate hyperuricemic nephropathy via modulation of purine metabolism, antiinflammation, and antifibrosis
by: Rui Gui, et al.
Published: (2023-04-01)

Mycorrhizal Fungi Synergistically Promote the Growth and Secondary Metabolism of <i>Cyclocarya paliurus</i>
by: Tingting Zhao, et al.
Published: (2022-12-01)

Antidiabetic Effect of Cyclocarya paliurus Leaves Depends on the Contents of Antihyperglycemic Flavonoids and Antihyperlipidemic Triterpenoids
by: Yang Liu, et al.
Published: (2018-04-01)

Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study
by: Lixiang Zhai, et al.
Published: (2018-08-01)

Antidiabetic effects and mechanisms of Cyclocarya paliurus leaf flavonoids via PIK3CA
by: Yanjun Wang, et al.
Published: (2024-02-01)

Effects on the Synthesis and Accumulation of Triterpenes in Leaves of <i>Cyclocarya paliurus</i> under MeJA Treatment
by: Qinghui Xia, et al.
Published: (2023-08-01)

Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities
by: Xianchao Shang, et al.
Published: (2018-08-01)

Ecological Gradient Analysis and Environmental Interpretation of <i>Cyclocarya paliurus</i> Communities
by: Caowen Sun, et al.
Published: (2021-01-01)

Hepatic lipidomics and proteomics analysis reveals the mechanism of Cyclocarya paliurus flavonoids in preventing non-alcoholic steatohepatitis in mice
by: Yu-Yan Wang, et al.
Published: (2022-12-01)

Potential hypoglycemic and hypolipidemic bioactive constituents in Cyclocarya paliurus leaves explored by affinity ultrafiltration with α‐glucosidase and pancreatic lipase
by: Mengjia Xu, et al.
Published: (2024-02-01)

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of <i>Cyclocarya paliurus</i> (Batal.) Iljinskaja Leaves
by: Mingming Zhou, et al.
Published: (2019-07-01)

Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and Systematic Review
by: Wei Liu, et al.
Published: (2020-12-01)