Cognitive impairments predict the behavioral and psychological symptoms of dementia
IntroductionThe purpose of this study was to (1) validate the Thai version of the Neuropsychiatric Inventory Questionnaire (NPI-Q) as a screening tool for behavioral and psychological symptoms of dementia (BPSD), and (2) examine the relationship between cognitive performance and BPSD in an elderly p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1194917/full |
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| author | Solaphat Hemrungrojn Solaphat Hemrungrojn Sookjaroen Tangwongchai Sookjaroen Tangwongchai Thammanard Charernboon Muthita Phanasathit Pisit Chaipresertsud Pacharaporn Maleevach Yuttachai Likitjaroen Kammant Phanthumchinda Ratiya Assawatinna Arisara Amrapala Arisara Amrapala Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes |
| author_facet | Solaphat Hemrungrojn Solaphat Hemrungrojn Sookjaroen Tangwongchai Sookjaroen Tangwongchai Thammanard Charernboon Muthita Phanasathit Pisit Chaipresertsud Pacharaporn Maleevach Yuttachai Likitjaroen Kammant Phanthumchinda Ratiya Assawatinna Arisara Amrapala Arisara Amrapala Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes |
| author_sort | Solaphat Hemrungrojn |
| collection | DOAJ |
| description | IntroductionThe purpose of this study was to (1) validate the Thai version of the Neuropsychiatric Inventory Questionnaire (NPI-Q) as a screening tool for behavioral and psychological symptoms of dementia (BPSD), and (2) examine the relationship between cognitive performance and BPSD in an elderly population with amnestic mild cognitive impairment (aMCI) and dementia of Alzheimer’s type (DAT).MethodsOne hundred and twenty participants, comprising 80 aMCI and 40 DAT patients, and their respective caregivers were included in the study. Participants completed the NPI-Q and the Neuropsychiatric Inventory (NPI) within 2 weeks of each other and cognitive performance was primarily assessed using the Montreal Cognitive Assessment (MoCA).ResultsThe Thai NPI-Q had good validity and reliability. Pure exploratory bifactor analysis revealed that a general factor and a single-group factor (with high loadings on delusions, hallucinations, apathy, and appetite) underpinned the NPI-Q domains. Significant negative correlations between the MoCA total score and the general and single-group NPI-Q scores were found in all subjects (aMCI + DAT combined) and DAT alone, but not in aMCI. Cluster analysis allocated subjects with BPSD (10% of aMCI and 50% of DAT participants) into a distinct “DAT + BPSD” class.ConclusionThe NPI-Q is an appropriate instrument for assessing BPSD and the total score is largely predicted by cognitive deficits. It is plausible that aMCI subjects with severe NPI-Q symptoms (10% of our sample) may have a poorer prognosis and constitute a subgroup of aMCI patients who will likely convert into probable dementia. |
| first_indexed | 2024-03-12T22:45:18Z |
| format | Article |
| id | doaj.art-8805863089a643b3bc074b9ad6348cbf |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T22:45:18Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-8805863089a643b3bc074b9ad6348cbf2023-07-21T07:54:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.11949171194917Cognitive impairments predict the behavioral and psychological symptoms of dementiaSolaphat Hemrungrojn0Solaphat Hemrungrojn1Sookjaroen Tangwongchai2Sookjaroen Tangwongchai3Thammanard Charernboon4Muthita Phanasathit5Pisit Chaipresertsud6Pacharaporn Maleevach7Yuttachai Likitjaroen8Kammant Phanthumchinda9Ratiya Assawatinna10Arisara Amrapala11Arisara Amrapala12Michael Maes13Michael Maes14Michael Maes15Michael Maes16Michael Maes17Michael Maes18Michael Maes19Department of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, ThailandCognitive Fitness and Biopsychiatry Technology Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, ThailandCognitive Impairment and Dementia Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathumthani, ThailandDepartment of Psychiatry, Faculty of Medicine, Thammasat University, Pathumthani, ThailandChao Phraya Abhaibhubejhr Hospital, Prachinburi, ThailandAngthong Hospital, Ang Thong, ThailandDivision of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDivision of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCognitive Fitness and Biopsychiatry Technology Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, ThailandCognitive Fitness and Biopsychiatry Technology Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, ThailandCognitive Fitness and Biopsychiatry Technology Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCognitive Impairment and Dementia Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Psychiatry, Medical University of Plovdiv and Technological Center for Emergency Medicine, Plovdiv, Bulgaria1Mental Health Center, University of Electronic Science and Technology of China, Chengdu, China1Mental Health Center, University of Electronic Science and Technology of China, Chengdu, China2Research Institute, Medical University of Plovdiv, Plovdiv, BulgariaIntroductionThe purpose of this study was to (1) validate the Thai version of the Neuropsychiatric Inventory Questionnaire (NPI-Q) as a screening tool for behavioral and psychological symptoms of dementia (BPSD), and (2) examine the relationship between cognitive performance and BPSD in an elderly population with amnestic mild cognitive impairment (aMCI) and dementia of Alzheimer’s type (DAT).MethodsOne hundred and twenty participants, comprising 80 aMCI and 40 DAT patients, and their respective caregivers were included in the study. Participants completed the NPI-Q and the Neuropsychiatric Inventory (NPI) within 2 weeks of each other and cognitive performance was primarily assessed using the Montreal Cognitive Assessment (MoCA).ResultsThe Thai NPI-Q had good validity and reliability. Pure exploratory bifactor analysis revealed that a general factor and a single-group factor (with high loadings on delusions, hallucinations, apathy, and appetite) underpinned the NPI-Q domains. Significant negative correlations between the MoCA total score and the general and single-group NPI-Q scores were found in all subjects (aMCI + DAT combined) and DAT alone, but not in aMCI. Cluster analysis allocated subjects with BPSD (10% of aMCI and 50% of DAT participants) into a distinct “DAT + BPSD” class.ConclusionThe NPI-Q is an appropriate instrument for assessing BPSD and the total score is largely predicted by cognitive deficits. It is plausible that aMCI subjects with severe NPI-Q symptoms (10% of our sample) may have a poorer prognosis and constitute a subgroup of aMCI patients who will likely convert into probable dementia.https://www.frontiersin.org/articles/10.3389/fneur.2023.1194917/fullcognitive dysfunctionbehavioral dysfunctionAlzheimer’s diseasepsychiatryneuropsychiatric symptomsmemory |
| spellingShingle | Solaphat Hemrungrojn Solaphat Hemrungrojn Sookjaroen Tangwongchai Sookjaroen Tangwongchai Thammanard Charernboon Muthita Phanasathit Pisit Chaipresertsud Pacharaporn Maleevach Yuttachai Likitjaroen Kammant Phanthumchinda Ratiya Assawatinna Arisara Amrapala Arisara Amrapala Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Michael Maes Cognitive impairments predict the behavioral and psychological symptoms of dementia Frontiers in Neurology cognitive dysfunction behavioral dysfunction Alzheimer’s disease psychiatry neuropsychiatric symptoms memory |
| title | Cognitive impairments predict the behavioral and psychological symptoms of dementia |
| title_full | Cognitive impairments predict the behavioral and psychological symptoms of dementia |
| title_fullStr | Cognitive impairments predict the behavioral and psychological symptoms of dementia |
| title_full_unstemmed | Cognitive impairments predict the behavioral and psychological symptoms of dementia |
| title_short | Cognitive impairments predict the behavioral and psychological symptoms of dementia |
| title_sort | cognitive impairments predict the behavioral and psychological symptoms of dementia |
| topic | cognitive dysfunction behavioral dysfunction Alzheimer’s disease psychiatry neuropsychiatric symptoms memory |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1194917/full |
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