Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?

Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?

Epstein-Barr virus (EBV) is an ubiquitous herpesvirus with a tropism for epithelial cells (where lytic replication occurs) and B-cells (where latency is maintained). EBV persists throughout life and chronic infection is asymptomatic in most individuals. However, immunocompromised patients may be una...

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Bibliographic Details
Main Authors: Moussab Tatfi, Olivier Hermine, Felipe Suarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
ataxia telangiectasia
Epstein Barr virus
latency
B-cell
primary immune deficiency
lymphomagenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03060/full

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