Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study
(1) Background: Vitamin K deficiency is a common feature of chronic kidney disease (CKD), leading to impaired bone quality and an increased risk of vascular calcifications. A method to indirectly assess the vitamin K status is measuring the blood level of vitamin K-dependent proteins (VKDP): osteoca...
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MDPI AG
2023-10-01
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| Online Access: | https://www.mdpi.com/2076-3417/13/19/10938 |
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| author | Marcel Palamar Iulia Grosu Adalbert Schiller Ligia Petrica Madalina Bodea Alexandru Sircuta Cornel Rusan Daniela Maria Tanasescu Flaviu Bob |
| author_facet | Marcel Palamar Iulia Grosu Adalbert Schiller Ligia Petrica Madalina Bodea Alexandru Sircuta Cornel Rusan Daniela Maria Tanasescu Flaviu Bob |
| author_sort | Marcel Palamar |
| collection | DOAJ |
| description | (1) Background: Vitamin K deficiency is a common feature of chronic kidney disease (CKD), leading to impaired bone quality and an increased risk of vascular calcifications. A method to indirectly assess the vitamin K status is measuring the blood level of vitamin K-dependent proteins (VKDP): osteocalcin (OC) and matrix GLA protein (MGP). The aim of this study is to correlate the level of total OC and inactive MGP (dp-uc MGP) with markers of CKD mineral bone disorder (CKD-MBD). (2) Methods: We conducted a single-center cross-sectional study that included 45 CKD G5D patients and measured their blood biochemistry, complete blood count and total osteocalcin and dp-uc MGP contents. (3) Results: We found a strong, statistically significant correlation of the total OC with the markers of CKD-MBD, such as: iPTH, serum calcium and serum phosphorus, and a strong, indirect statistically significant correlation with abdominal circumference. There was also a statistically significant correlation of dp-uc MGP with the markers of inflammation (CRP). Higher levels of dp-uc MGP were found in the patients treated with vitamin K antagonists, non-calcium-based phosphate binders and the vitamin D receptor activator, paricalcitol. (4) Conclusions: In our study, we found that when it is measured indirectly using VKDP levels, vitamin K deficiency is associated with CKD-MBD. Certain widely used medications such as phosphate binders reduce vitamin K absorption, supplementary vitamin D increases vitamin K requirements, and also vitamin K antagonists influence the blood level of VKDPs. |
| first_indexed | 2024-03-10T21:48:44Z |
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| last_indexed | 2024-03-10T21:48:44Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-8806870ef0d14f4286f511c50dedc9cd2023-11-19T14:06:19ZengMDPI AGApplied Sciences2076-34172023-10-0113191093810.3390/app131910938Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional StudyMarcel Palamar0Iulia Grosu1Adalbert Schiller2Ligia Petrica3Madalina Bodea4Alexandru Sircuta5Cornel Rusan6Daniela Maria Tanasescu7Flaviu Bob8Deva Emergency County Hospital, 330004 Deva, RomaniaCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, RomaniaCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, RomaniaCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, RomaniaCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, RomaniaCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDialysis, Fresenius Nephrocare Deva, 330004 Deva, RomaniaNephrology Department, Bucharest Emergency University Hospital, 050098 Bucharest, RomaniaCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania(1) Background: Vitamin K deficiency is a common feature of chronic kidney disease (CKD), leading to impaired bone quality and an increased risk of vascular calcifications. A method to indirectly assess the vitamin K status is measuring the blood level of vitamin K-dependent proteins (VKDP): osteocalcin (OC) and matrix GLA protein (MGP). The aim of this study is to correlate the level of total OC and inactive MGP (dp-uc MGP) with markers of CKD mineral bone disorder (CKD-MBD). (2) Methods: We conducted a single-center cross-sectional study that included 45 CKD G5D patients and measured their blood biochemistry, complete blood count and total osteocalcin and dp-uc MGP contents. (3) Results: We found a strong, statistically significant correlation of the total OC with the markers of CKD-MBD, such as: iPTH, serum calcium and serum phosphorus, and a strong, indirect statistically significant correlation with abdominal circumference. There was also a statistically significant correlation of dp-uc MGP with the markers of inflammation (CRP). Higher levels of dp-uc MGP were found in the patients treated with vitamin K antagonists, non-calcium-based phosphate binders and the vitamin D receptor activator, paricalcitol. (4) Conclusions: In our study, we found that when it is measured indirectly using VKDP levels, vitamin K deficiency is associated with CKD-MBD. Certain widely used medications such as phosphate binders reduce vitamin K absorption, supplementary vitamin D increases vitamin K requirements, and also vitamin K antagonists influence the blood level of VKDPs.https://www.mdpi.com/2076-3417/13/19/10938hemodialysiscalcificationsvitamin Kosteocalcinmatrix Gla protein |
| spellingShingle | Marcel Palamar Iulia Grosu Adalbert Schiller Ligia Petrica Madalina Bodea Alexandru Sircuta Cornel Rusan Daniela Maria Tanasescu Flaviu Bob Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study Applied Sciences hemodialysis calcifications vitamin K osteocalcin matrix Gla protein |
| title | Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study |
| title_full | Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study |
| title_fullStr | Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study |
| title_full_unstemmed | Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study |
| title_short | Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study |
| title_sort | vitamin k status of patients undergoing hemodialysis insights from a cross sectional study |
| topic | hemodialysis calcifications vitamin K osteocalcin matrix Gla protein |
| url | https://www.mdpi.com/2076-3417/13/19/10938 |
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