Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs

Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs

Thrombosis is common in critically ill dogs and causes considerable morbidity and mortality. The direct factor Xa inhibitor apixaban is safe, efficacious, and convenient in humans. This study aimed to determine the pharmacokinetics (PK), bioactivity, protein binding, and bioavailability of apixaban...

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Bibliographic Details
Main Authors: Noelle D. Herrera, Ingvild Birschmann, Monika Wolny, Mark G. Papich, Marjory B. Brooks, Robert Goggs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Veterinary Science
Subjects:
antithrombotic
anti-Xa activity
direct oral anticoagulant
thrombosis
thromboelastography
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2021.702821/full

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