Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population
Lung cancer is one of the most frequently occurring cancers throughout the world as well as in Bangladesh. This study aimed to correlate the prognostic and/or predictive value of functional polymorphisms in SULT1A1 (rs9282861) and XRCC1 (rs25487) genes and lung cancer risk in Bangladeshi population....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2017-10-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317729270 |
| _version_ | 1819135290315374592 |
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| author | Tasnova Tasnim Mir Md Abdullah Al-Mamun Noor Ahmed Nahid Md Reazul Islam Mohd Nazmul Hasan Apu Most Umme Bushra Sikder Nahidul Islam Rabbi Zabun Nahar Jakir Ahmed Chowdhury Maizbha Uddin Ahmed Mohammad Safiqul Islam Abul Hasnat |
| author_facet | Tasnova Tasnim Mir Md Abdullah Al-Mamun Noor Ahmed Nahid Md Reazul Islam Mohd Nazmul Hasan Apu Most Umme Bushra Sikder Nahidul Islam Rabbi Zabun Nahar Jakir Ahmed Chowdhury Maizbha Uddin Ahmed Mohammad Safiqul Islam Abul Hasnat |
| author_sort | Tasnova Tasnim |
| collection | DOAJ |
| description | Lung cancer is one of the most frequently occurring cancers throughout the world as well as in Bangladesh. This study aimed to correlate the prognostic and/or predictive value of functional polymorphisms in SULT1A1 (rs9282861) and XRCC1 (rs25487) genes and lung cancer risk in Bangladeshi population. A case-control study was conducted which comprises 202 lung cancer patients and 242 healthy volunteers taking into account the age, sex, and smoking status. After isolation of genomic DNA, genotyping was done by polymerase chain reaction–restriction fragment length polymorphism method and the lung cancer risk was evaluated as odds ratio that was adjusted for age, sex, and smoking status. A significant association was found between SULT1A1 rs9282861 and XRCC1 rs25487 polymorphisms and lung cancer risk. In case of rs9282861 polymorphism, Arg/His (adjusted odds ratio = 5.06, 95% confidence interval = 3.05–8.41, p < 0.05) and His/His (adjusted odds ratio = 3.88, 95% confidence interval = 2.20–6.82, p < 0.05) genotypes were strongly associated with increased risk of lung cancer in comparison to the Arg/Arg genotype. In case of rs25487 polymorphism, Arg/Gln heterozygote (adjusted odds ratio = 4.57, 95% confidence interval = 2.79–7.46, p < 0.05) and Gln/Gln mutant homozygote (adjusted odds ratio = 4.99, 95% confidence interval = 2.66–9.36, p < 0.05) were also found to be significantly associated with increased risk of lung cancer. This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population. |
| first_indexed | 2024-12-22T10:16:44Z |
| format | Article |
| id | doaj.art-880a28ccc21e49e3a2ce4c943a643305 |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-22T10:16:44Z |
| publishDate | 2017-10-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-880a28ccc21e49e3a2ce4c943a6433052022-12-21T18:29:43ZengIOS PressTumor Biology1423-03802017-10-013910.1177/1010428317729270Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi populationTasnova Tasnim0Mir Md Abdullah Al-Mamun1Noor Ahmed Nahid2Md Reazul Islam3Mohd Nazmul Hasan Apu4Most Umme Bushra5Sikder Nahidul Islam Rabbi6Zabun Nahar7Jakir Ahmed Chowdhury8Maizbha Uddin Ahmed9Mohammad Safiqul Islam10Abul Hasnat11Department of Pharmacy, University of Asia Pacific, Dhaka, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshPharmacogenetics Lab, Labaid Ltd, Dhaka, BangladeshDepartment of Pharmacy, University of Asia Pacific, Dhaka, BangladeshDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, BangladeshLung cancer is one of the most frequently occurring cancers throughout the world as well as in Bangladesh. This study aimed to correlate the prognostic and/or predictive value of functional polymorphisms in SULT1A1 (rs9282861) and XRCC1 (rs25487) genes and lung cancer risk in Bangladeshi population. A case-control study was conducted which comprises 202 lung cancer patients and 242 healthy volunteers taking into account the age, sex, and smoking status. After isolation of genomic DNA, genotyping was done by polymerase chain reaction–restriction fragment length polymorphism method and the lung cancer risk was evaluated as odds ratio that was adjusted for age, sex, and smoking status. A significant association was found between SULT1A1 rs9282861 and XRCC1 rs25487 polymorphisms and lung cancer risk. In case of rs9282861 polymorphism, Arg/His (adjusted odds ratio = 5.06, 95% confidence interval = 3.05–8.41, p < 0.05) and His/His (adjusted odds ratio = 3.88, 95% confidence interval = 2.20–6.82, p < 0.05) genotypes were strongly associated with increased risk of lung cancer in comparison to the Arg/Arg genotype. In case of rs25487 polymorphism, Arg/Gln heterozygote (adjusted odds ratio = 4.57, 95% confidence interval = 2.79–7.46, p < 0.05) and Gln/Gln mutant homozygote (adjusted odds ratio = 4.99, 95% confidence interval = 2.66–9.36, p < 0.05) were also found to be significantly associated with increased risk of lung cancer. This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population.https://doi.org/10.1177/1010428317729270 |
| spellingShingle | Tasnova Tasnim Mir Md Abdullah Al-Mamun Noor Ahmed Nahid Md Reazul Islam Mohd Nazmul Hasan Apu Most Umme Bushra Sikder Nahidul Islam Rabbi Zabun Nahar Jakir Ahmed Chowdhury Maizbha Uddin Ahmed Mohammad Safiqul Islam Abul Hasnat Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population Tumor Biology |
| title | Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population |
| title_full | Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population |
| title_fullStr | Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population |
| title_full_unstemmed | Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population |
| title_short | Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population |
| title_sort | genetic variants of sult1a1 and xrcc1 genes and risk of lung cancer in bangladeshi population |
| url | https://doi.org/10.1177/1010428317729270 |
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