INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS
Background. Coumarins are natural compounds (secondary metabolites of plant origin) that have a wide range of biological activity, mainly due to their ability to interact with various enzymes and receptors in living organisms. The relevance of their use in feeding poultry is obvious, in view of the...
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| Format: | Article |
| Language: | English |
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Science and Innovation Center Publishing House
2023-06-01
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| Series: | Siberian Journal of Life Sciences and Agriculture |
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| Online Access: | http://discover-journal.ru/jour/index.php/sjlsa/article/view/799 |
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| author | Galimzhan K. Duskaev Tatyana A. Klimova |
| author_facet | Galimzhan K. Duskaev Tatyana A. Klimova |
| author_sort | Galimzhan K. Duskaev |
| collection | DOAJ |
| description | Background. Coumarins are natural compounds (secondary metabolites of plant origin) that have a wide range of biological activity, mainly due to their ability to interact with various enzymes and receptors in living organisms. The relevance of their use in feeding poultry is obvious, in view of the active search for alternatives to feed antibiotics.
The aim of the study was to evaluate the effect of coumarin on the productivity and antioxidant status of broiler chickens.
Materials and methods. Objects of study: broiler chickens of the Arbor Acres cross, 7-hydroxycoumarin. The experiment was carried out on 180 heads of 7-day-old broiler chickens (n=45). Control - the main diet (OR), 1 experimental – OR + coumarin (at a dose of 1 mg/kg of feed/day, 2 experimental – OR + coumarin at a dose of 2 mg/kg of feed / day, 3 experimental – OR + coumarin in at a dose of 3 mg/kg feed/day. Hematological parameters (number and type of leukocytes) were taken into account on an automatic hematological analyzer URIT-2900 Vet Plus (URIT Medical Electronic Group Co., Ltd, China). Biochemical analysis of blood serum was performed on an automatic biochemical analyzer CS-T240 (Dirui Industrial Co., Ltd, China).
Results. The inclusion of 7-hydroxycoumarin in the diet contributed to an increase in live weight in the experimental groups by 8,6–19,4%; (by 9,2–21,1%), slaughter yield (up to 4,76%), against the background of a decrease in feed consumption per 1 kg of live weight gain (by 3,5–15,7%). showed a decrease in total protein, albumin, ALT (groups 1 and 2 (p≤0,05)), bilirubin (by 38,3–68,6%), cholesterol (in group 3 by 16,4% (p≤0,05)), triglycerides (groups 1 and 2, p≤0,05), urea (41,8–65,1%; p≤0,05), against the background of elevated iron levels (groups 1 and 2, p≤0,05). Depending on the dose of 7-hydroxycoumarin, a decrease in the number of leukocytes (group 1, p≤0,05), neutrophils (groups 1 and 2, p≤0,05), monocytes, eosinophils and basophils (p≤ 0,05). Antioxidant indicators were characterized by a decrease in the level of malondialdehyde (by 63,7–77,3%), superoxide dismutase activity (22,4–71,5%) and an increase in catalase activity (by 24,3–46,1%).
Conclusion. Thus, the inclusion of 7-hydroxycoumarin (2 mg/kg feed/day) in the diet contributed to an increase in the live weight of broiler chickens, feed intake, slaughter yield, against the background of a lower feed consumption per 1 kg of live weight gain; had a positive effect on the parameters of the liver (ALT, total bilirubin), lipid and nitrogen metabolism (triglycerides, urea), the antioxidant status of the body of broiler chickens. |
| first_indexed | 2024-03-12T13:26:36Z |
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| issn | 2658-6649 2658-6657 |
| language | English |
| last_indexed | 2024-03-12T13:26:36Z |
| publishDate | 2023-06-01 |
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| series | Siberian Journal of Life Sciences and Agriculture |
| spelling | doaj.art-880a390caa69482783c9c5652d2bfbd42023-08-25T04:43:15ZengScience and Innovation Center Publishing HouseSiberian Journal of Life Sciences and Agriculture2658-66492658-66572023-06-0115319721810.12731/2658-6649-2023-15-3-197-218799INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERSGalimzhan K. Duskaev0Tatyana A. Klimova1Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of SciencesFederal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of SciencesBackground. Coumarins are natural compounds (secondary metabolites of plant origin) that have a wide range of biological activity, mainly due to their ability to interact with various enzymes and receptors in living organisms. The relevance of their use in feeding poultry is obvious, in view of the active search for alternatives to feed antibiotics. The aim of the study was to evaluate the effect of coumarin on the productivity and antioxidant status of broiler chickens. Materials and methods. Objects of study: broiler chickens of the Arbor Acres cross, 7-hydroxycoumarin. The experiment was carried out on 180 heads of 7-day-old broiler chickens (n=45). Control - the main diet (OR), 1 experimental – OR + coumarin (at a dose of 1 mg/kg of feed/day, 2 experimental – OR + coumarin at a dose of 2 mg/kg of feed / day, 3 experimental – OR + coumarin in at a dose of 3 mg/kg feed/day. Hematological parameters (number and type of leukocytes) were taken into account on an automatic hematological analyzer URIT-2900 Vet Plus (URIT Medical Electronic Group Co., Ltd, China). Biochemical analysis of blood serum was performed on an automatic biochemical analyzer CS-T240 (Dirui Industrial Co., Ltd, China). Results. The inclusion of 7-hydroxycoumarin in the diet contributed to an increase in live weight in the experimental groups by 8,6–19,4%; (by 9,2–21,1%), slaughter yield (up to 4,76%), against the background of a decrease in feed consumption per 1 kg of live weight gain (by 3,5–15,7%). showed a decrease in total protein, albumin, ALT (groups 1 and 2 (p≤0,05)), bilirubin (by 38,3–68,6%), cholesterol (in group 3 by 16,4% (p≤0,05)), triglycerides (groups 1 and 2, p≤0,05), urea (41,8–65,1%; p≤0,05), against the background of elevated iron levels (groups 1 and 2, p≤0,05). Depending on the dose of 7-hydroxycoumarin, a decrease in the number of leukocytes (group 1, p≤0,05), neutrophils (groups 1 and 2, p≤0,05), monocytes, eosinophils and basophils (p≤ 0,05). Antioxidant indicators were characterized by a decrease in the level of malondialdehyde (by 63,7–77,3%), superoxide dismutase activity (22,4–71,5%) and an increase in catalase activity (by 24,3–46,1%). Conclusion. Thus, the inclusion of 7-hydroxycoumarin (2 mg/kg feed/day) in the diet contributed to an increase in the live weight of broiler chickens, feed intake, slaughter yield, against the background of a lower feed consumption per 1 kg of live weight gain; had a positive effect on the parameters of the liver (ALT, total bilirubin), lipid and nitrogen metabolism (triglycerides, urea), the antioxidant status of the body of broiler chickens.http://discover-journal.ru/jour/index.php/sjlsa/article/view/799broiler chickenscoumarinlive weightblood biochemistryantioxidant indicatorswhite blood cells |
| spellingShingle | Galimzhan K. Duskaev Tatyana A. Klimova INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS Siberian Journal of Life Sciences and Agriculture broiler chickens coumarin live weight blood biochemistry antioxidant indicators white blood cells |
| title | INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS |
| title_full | INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS |
| title_fullStr | INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS |
| title_full_unstemmed | INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS |
| title_short | INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS |
| title_sort | influence of coumarin on productivity immunity and antioxidant status of healthy broilers |
| topic | broiler chickens coumarin live weight blood biochemistry antioxidant indicators white blood cells |
| url | http://discover-journal.ru/jour/index.php/sjlsa/article/view/799 |
| work_keys_str_mv | AT galimzhankduskaev influenceofcoumarinonproductivityimmunityandantioxidantstatusofhealthybroilers AT tatyanaaklimova influenceofcoumarinonproductivityimmunityandantioxidantstatusofhealthybroilers |