Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment
Psoriasis is a chronic inflammatory systemic disease primarily affecting the skin, but which often involves considerable comorbidities as well. One-third of psoriasis cases start during childhood. In pediatric psoriasis, an association with several medical comorbidities is also indicated. Furthermor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/8/940 |
| _version_ | 1797524585824911360 |
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| author | Hye One Kim Seok Young Kang Jin Cheol Kim Chun Wook Park Bo Young Chung |
| author_facet | Hye One Kim Seok Young Kang Jin Cheol Kim Chun Wook Park Bo Young Chung |
| author_sort | Hye One Kim |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory systemic disease primarily affecting the skin, but which often involves considerable comorbidities as well. One-third of psoriasis cases start during childhood. In pediatric psoriasis, an association with several medical comorbidities is also indicated. Furthermore, because of its chronic nature and frequent relapses, psoriatic patients tend to require long-term treatment and experience negative impacts on their quality of life. Considering the different clinical characteristics of pediatric psoriasis, it has recently been presented that the pathogenesis of pediatric psoriasis is distinct from adult psoriasis. Treatment for pediatric psoriasis usually involves the same methods as for adults. However, most treatments in pediatric psoriasis are used off-label and research in this regard is still lacking. Targeted therapies involving newly developed biologics are also increasingly being applied to psoriasis in children. This review summarizes the clinical characteristics of pediatric psoriasis and focuses mainly on the updated concepts of pathogenesis and treatments in pediatric psoriasis. This was undertaken to widen the understanding of these relevant aspects and to provide better management of pediatric psoriasis by clinicians. |
| first_indexed | 2024-03-10T08:59:33Z |
| format | Article |
| id | doaj.art-880a8a336aba40a2a9d4d00285ad5f26 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T08:59:33Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-880a8a336aba40a2a9d4d00285ad5f262023-11-22T06:52:19ZengMDPI AGBiomedicines2227-90592021-08-019894010.3390/biomedicines9080940Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on TreatmentHye One Kim0Seok Young Kang1Jin Cheol Kim2Chun Wook Park3Bo Young Chung4Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, KoreaDepartment of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, KoreaDepartment of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, KoreaDepartment of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, KoreaDepartment of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, KoreaPsoriasis is a chronic inflammatory systemic disease primarily affecting the skin, but which often involves considerable comorbidities as well. One-third of psoriasis cases start during childhood. In pediatric psoriasis, an association with several medical comorbidities is also indicated. Furthermore, because of its chronic nature and frequent relapses, psoriatic patients tend to require long-term treatment and experience negative impacts on their quality of life. Considering the different clinical characteristics of pediatric psoriasis, it has recently been presented that the pathogenesis of pediatric psoriasis is distinct from adult psoriasis. Treatment for pediatric psoriasis usually involves the same methods as for adults. However, most treatments in pediatric psoriasis are used off-label and research in this regard is still lacking. Targeted therapies involving newly developed biologics are also increasingly being applied to psoriasis in children. This review summarizes the clinical characteristics of pediatric psoriasis and focuses mainly on the updated concepts of pathogenesis and treatments in pediatric psoriasis. This was undertaken to widen the understanding of these relevant aspects and to provide better management of pediatric psoriasis by clinicians.https://www.mdpi.com/2227-9059/9/8/940psoriasispediatricchildhoodpathogenesistopical treatmentsystemic treatment |
| spellingShingle | Hye One Kim Seok Young Kang Jin Cheol Kim Chun Wook Park Bo Young Chung Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment Biomedicines psoriasis pediatric childhood pathogenesis topical treatment systemic treatment |
| title | Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment |
| title_full | Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment |
| title_fullStr | Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment |
| title_full_unstemmed | Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment |
| title_short | Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment |
| title_sort | pediatric psoriasis from new insights into pathogenesis to updates on treatment |
| topic | psoriasis pediatric childhood pathogenesis topical treatment systemic treatment |
| url | https://www.mdpi.com/2227-9059/9/8/940 |
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