The role of lymphatics in intestinal inflammation
Abstract The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn’s disease, obesit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Inflammation and Regeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41232-021-00175-6 |
| _version_ | 1819124821180547072 |
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| author | Ryota Hokari Akira Tomioka |
| author_facet | Ryota Hokari Akira Tomioka |
| author_sort | Ryota Hokari |
| collection | DOAJ |
| description | Abstract The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn’s disease, obesity, cardiovascular disease, hypertension, atherosclerosis, and Alzheimer’s disease. In this review, we discuss lymphatic structure and function within the gut, such as dietary lipid absorption, the transport of antigens and immune cells to lymph nodes, peripheral tolerance, and lymphocyte migration from secondary lymphoid tissues to the lymphatics and the immune systems. We also discuss the potential roles of these lymphatics on the pathophysiology of inflammatory bowel disease and as new targets for therapeutic management. |
| first_indexed | 2024-12-22T07:30:20Z |
| format | Article |
| id | doaj.art-880ae1c9dd8347d5a022ddb80456e0f4 |
| institution | Directory Open Access Journal |
| issn | 1880-8190 |
| language | English |
| last_indexed | 2024-12-22T07:30:20Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Inflammation and Regeneration |
| spelling | doaj.art-880ae1c9dd8347d5a022ddb80456e0f42022-12-21T18:34:02ZengBMCInflammation and Regeneration1880-81902021-08-014111710.1186/s41232-021-00175-6The role of lymphatics in intestinal inflammationRyota Hokari0Akira Tomioka1Department of Internal Medicine, National Defense Medical CollegeDepartment of Internal Medicine, National Defense Medical CollegeAbstract The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn’s disease, obesity, cardiovascular disease, hypertension, atherosclerosis, and Alzheimer’s disease. In this review, we discuss lymphatic structure and function within the gut, such as dietary lipid absorption, the transport of antigens and immune cells to lymph nodes, peripheral tolerance, and lymphocyte migration from secondary lymphoid tissues to the lymphatics and the immune systems. We also discuss the potential roles of these lymphatics on the pathophysiology of inflammatory bowel disease and as new targets for therapeutic management.https://doi.org/10.1186/s41232-021-00175-6Lymphatic vasculatureInflammationLipid absorption |
| spellingShingle | Ryota Hokari Akira Tomioka The role of lymphatics in intestinal inflammation Inflammation and Regeneration Lymphatic vasculature Inflammation Lipid absorption |
| title | The role of lymphatics in intestinal inflammation |
| title_full | The role of lymphatics in intestinal inflammation |
| title_fullStr | The role of lymphatics in intestinal inflammation |
| title_full_unstemmed | The role of lymphatics in intestinal inflammation |
| title_short | The role of lymphatics in intestinal inflammation |
| title_sort | role of lymphatics in intestinal inflammation |
| topic | Lymphatic vasculature Inflammation Lipid absorption |
| url | https://doi.org/10.1186/s41232-021-00175-6 |
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