Galectin-3 and peripheral artery disease: a Mendelian randomization study
BackgroundMultiple clinical studies have found a significant correlation between elevated galectin-3 (Gal-3) in circulation and the diagnosis and severity of peripheral arterial disease (PAD). The current study used the Mendelian randomization (MR) technique to evaluate the possible causal relations...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1279396/full |
| _version_ | 1827391116057509888 |
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| author | Yang Gou Miao Chen Zhi Zhu Chi Cui |
| author_facet | Yang Gou Miao Chen Zhi Zhu Chi Cui |
| author_sort | Yang Gou |
| collection | DOAJ |
| description | BackgroundMultiple clinical studies have found a significant correlation between elevated galectin-3 (Gal-3) in circulation and the diagnosis and severity of peripheral arterial disease (PAD). The current study used the Mendelian randomization (MR) technique to evaluate the possible causal relationship between Gal-3 and PAD.MethodsGenome-wide association study (GWAS) data of Gal-3 and PAD were obtained through the MR-Base platform. Then, using Gal-3 as the exposure and PAD as the outcome, a two-sample MR analysis was performed utilizing several regression techniques, including MR-Egger regression, inverse variance weighted (IVW), weighted median, and weighted mode.ResultsSix single-nucleotide polymorphisms (SNPs) were identified and designated as instrumental variables (IVs) that exhibited significant correlations with Gal-3 (linkage disequilibrium r2 < 0.001; P < 5 × 10−8). Various statistical methods showed that there was an absence of a significant link between Gal-3 and PAD (IVW: odds ratio (OR) = 0.9869, 95% confidence interval (CI) = 0.8792–1.1078, P = 0.8232). In addition, the presence of genetic pleiotropy did impact the putative causal relationship between PAD and Gal-3 (MR-Egger intercept = 0.0099, P = 0.659).ConclusionsThere is no current evidence to establish a causal relationship between the level of Gal-3 in circulation and PAD. |
| first_indexed | 2024-03-08T17:06:02Z |
| format | Article |
| id | doaj.art-880cee07daad414da82573b62a2aa3d9 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T17:06:02Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-880cee07daad414da82573b62a2aa3d92024-01-04T05:07:04ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-01-011010.3389/fcvm.2023.12793961279396Galectin-3 and peripheral artery disease: a Mendelian randomization studyYang GouMiao ChenZhi ZhuChi CuiBackgroundMultiple clinical studies have found a significant correlation between elevated galectin-3 (Gal-3) in circulation and the diagnosis and severity of peripheral arterial disease (PAD). The current study used the Mendelian randomization (MR) technique to evaluate the possible causal relationship between Gal-3 and PAD.MethodsGenome-wide association study (GWAS) data of Gal-3 and PAD were obtained through the MR-Base platform. Then, using Gal-3 as the exposure and PAD as the outcome, a two-sample MR analysis was performed utilizing several regression techniques, including MR-Egger regression, inverse variance weighted (IVW), weighted median, and weighted mode.ResultsSix single-nucleotide polymorphisms (SNPs) were identified and designated as instrumental variables (IVs) that exhibited significant correlations with Gal-3 (linkage disequilibrium r2 < 0.001; P < 5 × 10−8). Various statistical methods showed that there was an absence of a significant link between Gal-3 and PAD (IVW: odds ratio (OR) = 0.9869, 95% confidence interval (CI) = 0.8792–1.1078, P = 0.8232). In addition, the presence of genetic pleiotropy did impact the putative causal relationship between PAD and Gal-3 (MR-Egger intercept = 0.0099, P = 0.659).ConclusionsThere is no current evidence to establish a causal relationship between the level of Gal-3 in circulation and PAD.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1279396/fullgalectin-3peripheral artery diseaseMendelian randomizationcausalitySNPs (single-nucleotide polymorphisms) |
| spellingShingle | Yang Gou Miao Chen Zhi Zhu Chi Cui Galectin-3 and peripheral artery disease: a Mendelian randomization study Frontiers in Cardiovascular Medicine galectin-3 peripheral artery disease Mendelian randomization causality SNPs (single-nucleotide polymorphisms) |
| title | Galectin-3 and peripheral artery disease: a Mendelian randomization study |
| title_full | Galectin-3 and peripheral artery disease: a Mendelian randomization study |
| title_fullStr | Galectin-3 and peripheral artery disease: a Mendelian randomization study |
| title_full_unstemmed | Galectin-3 and peripheral artery disease: a Mendelian randomization study |
| title_short | Galectin-3 and peripheral artery disease: a Mendelian randomization study |
| title_sort | galectin 3 and peripheral artery disease a mendelian randomization study |
| topic | galectin-3 peripheral artery disease Mendelian randomization causality SNPs (single-nucleotide polymorphisms) |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1279396/full |
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