Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents

It is now established that the thieno[2,3-b]pyridines are a potent class of antiproliferatives. One of the main issues encountered for their clinical application is their low water solubility. In order to improve this, two strategies were pursued. First, a morpholine moiety was tethered to the molec...

Full description

Bibliographic Details
Main Authors: Ayesha Zafar, Lisa I. Pilkington, Natalie A. Haverkate, Michelle van Rensburg, Euphemia Leung, Sisira Kumara, William A. Denny, David Barker, Ali Alsuraifi, Clare Hoskins, Jóhannes Reynisson
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
morpholine substitution
1H-pyrrolo[2,3-b]pyridine
molecular modelling
nano aggregates
polymer formulation
Online Access:http://www.mdpi.com/1420-3049/23/1/145

Internet

http://www.mdpi.com/1420-3049/23/1/145

Similar Items