Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China.
BACKGROUND: Tuberculosis (TB) is a serious health problem in Tibet where Tibetans are the major ethnic group. Although genotyping of Mycobacterium tuberculosis (M. tuberculosis) isolates is a valuable tool for TB control, our knowledge of population structure of M. tuberculosis circulating in Tibet...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3316506?pdf=render |
| _version_ | 1818060321860878336 |
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| author | Haiyan Dong Li Shi Xiuqin Zhao Ba Sang Bing Lv Zhiguang Liu Kanglin Wan |
| author_facet | Haiyan Dong Li Shi Xiuqin Zhao Ba Sang Bing Lv Zhiguang Liu Kanglin Wan |
| author_sort | Haiyan Dong |
| collection | DOAJ |
| description | BACKGROUND: Tuberculosis (TB) is a serious health problem in Tibet where Tibetans are the major ethnic group. Although genotyping of Mycobacterium tuberculosis (M. tuberculosis) isolates is a valuable tool for TB control, our knowledge of population structure of M. tuberculosis circulating in Tibet is limited. METHODOLOGY/PRINCIPAL FINDINGS: In our study, a total of 576 M. tuberculosis isolates from Tibetans in Tibet, China, were analyzed via spoligotyping and 24-locus MIRU-VNTR. The Beijing genotype was the most prevalent family (90.63%, n = 522). Shared-type (ST) 1 was the most dominant genotype (88.89%, n = 512). We found that there was no association between the Beijing genotype and sex, age and treatment status. In this sample collection, 7 of the 24 MIRU-VNTR loci were highly or moderately discriminative according to their Hunter-Gaston discriminatory index. An informative set of 12 loci had similar discriminatory power with 24 loci set. CONCLUSIONS/SIGNIFICANCE: The population structure of M. tuberculosis isolates in Tibetans is homogeneous and dominated by Beijing genotype. The analysis of 24-locus MIRU-VNTR data might be useful to select appropriate VNTR loci for the genotyping of M. tuberculosis. |
| first_indexed | 2024-12-10T13:30:34Z |
| format | Article |
| id | doaj.art-881064d4107049cb9a9891c4932bcbf5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T13:30:34Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-881064d4107049cb9a9891c4932bcbf52022-12-22T01:46:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3390410.1371/journal.pone.0033904Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China.Haiyan DongLi ShiXiuqin ZhaoBa SangBing LvZhiguang LiuKanglin WanBACKGROUND: Tuberculosis (TB) is a serious health problem in Tibet where Tibetans are the major ethnic group. Although genotyping of Mycobacterium tuberculosis (M. tuberculosis) isolates is a valuable tool for TB control, our knowledge of population structure of M. tuberculosis circulating in Tibet is limited. METHODOLOGY/PRINCIPAL FINDINGS: In our study, a total of 576 M. tuberculosis isolates from Tibetans in Tibet, China, were analyzed via spoligotyping and 24-locus MIRU-VNTR. The Beijing genotype was the most prevalent family (90.63%, n = 522). Shared-type (ST) 1 was the most dominant genotype (88.89%, n = 512). We found that there was no association between the Beijing genotype and sex, age and treatment status. In this sample collection, 7 of the 24 MIRU-VNTR loci were highly or moderately discriminative according to their Hunter-Gaston discriminatory index. An informative set of 12 loci had similar discriminatory power with 24 loci set. CONCLUSIONS/SIGNIFICANCE: The population structure of M. tuberculosis isolates in Tibetans is homogeneous and dominated by Beijing genotype. The analysis of 24-locus MIRU-VNTR data might be useful to select appropriate VNTR loci for the genotyping of M. tuberculosis.http://europepmc.org/articles/PMC3316506?pdf=render |
| spellingShingle | Haiyan Dong Li Shi Xiuqin Zhao Ba Sang Bing Lv Zhiguang Liu Kanglin Wan Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China. PLoS ONE |
| title | Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China. |
| title_full | Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China. |
| title_fullStr | Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China. |
| title_full_unstemmed | Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China. |
| title_short | Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China. |
| title_sort | genetic diversity of mycobacterium tuberculosis isolates from tibetans in tibet china |
| url | http://europepmc.org/articles/PMC3316506?pdf=render |
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