Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release
The state of the art in the use of chitosan (CS) for preparing particulate carriers for drug delivery applications is reviewed. After evidencing the scientific and commercial potentials of CS, the links between targeted controlled activity, the preparation process and the kinetics of release are det...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/5/1455 |
| _version_ | 1797598682294517760 |
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| author | Jiaqi Weng Alain Durand Stéphane Desobry |
| author_facet | Jiaqi Weng Alain Durand Stéphane Desobry |
| author_sort | Jiaqi Weng |
| collection | DOAJ |
| description | The state of the art in the use of chitosan (CS) for preparing particulate carriers for drug delivery applications is reviewed. After evidencing the scientific and commercial potentials of CS, the links between targeted controlled activity, the preparation process and the kinetics of release are detailed, focusing on two types of particulate carriers: matrix particles and capsules. More precisely, the relationship between the size/structure of CS-based particles as multifunctional delivery systems and drug release kinetics (models) is emphasized. The preparation method and conditions greatly influence particle structure and size, which affect release properties. Various techniques available for characterizing particle structural properties and size distribution are reviewed. CS particulate carriers with different structures can achieve various release patterns, including zero-order, multi-pulsed, and pulse-triggered. Mathematical models have an unavoidable role in understanding release mechanisms and their interrelationships. Moreover, models help identify the key structural characteristics, thus saving experimental time. Furthermore, by investigating the close relation between preparation process parameters and particulate structural characteristics as well as their effect on release properties, a novel “on-demand” strategy for the design of drug delivery devices may be developed. This reverse strategy involves designing the production process and the related particles’ structure based on the targeted release pattern. |
| first_indexed | 2024-03-11T03:24:31Z |
| format | Article |
| id | doaj.art-88109212cb9744c693e57ee002b44166 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T03:24:31Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-88109212cb9744c693e57ee002b441662023-11-18T02:51:47ZengMDPI AGPharmaceutics1999-49232023-05-01155145510.3390/pharmaceutics15051455Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled ReleaseJiaqi Weng0Alain Durand1Stéphane Desobry2Université de Lorraine, LIBio, F-54000 Nancy, FranceUniversité de Lorraine, CNRS, LCPM, F-54000 Nancy, FranceUniversité de Lorraine, LIBio, F-54000 Nancy, FranceThe state of the art in the use of chitosan (CS) for preparing particulate carriers for drug delivery applications is reviewed. After evidencing the scientific and commercial potentials of CS, the links between targeted controlled activity, the preparation process and the kinetics of release are detailed, focusing on two types of particulate carriers: matrix particles and capsules. More precisely, the relationship between the size/structure of CS-based particles as multifunctional delivery systems and drug release kinetics (models) is emphasized. The preparation method and conditions greatly influence particle structure and size, which affect release properties. Various techniques available for characterizing particle structural properties and size distribution are reviewed. CS particulate carriers with different structures can achieve various release patterns, including zero-order, multi-pulsed, and pulse-triggered. Mathematical models have an unavoidable role in understanding release mechanisms and their interrelationships. Moreover, models help identify the key structural characteristics, thus saving experimental time. Furthermore, by investigating the close relation between preparation process parameters and particulate structural characteristics as well as their effect on release properties, a novel “on-demand” strategy for the design of drug delivery devices may be developed. This reverse strategy involves designing the production process and the related particles’ structure based on the targeted release pattern.https://www.mdpi.com/1999-4923/15/5/1455chitosancontrolled releaseparticlescapsules |
| spellingShingle | Jiaqi Weng Alain Durand Stéphane Desobry Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release Pharmaceutics chitosan controlled release particles capsules |
| title | Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release |
| title_full | Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release |
| title_fullStr | Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release |
| title_full_unstemmed | Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release |
| title_short | Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release |
| title_sort | chitosan based particulate carriers structure production and corresponding controlled release |
| topic | chitosan controlled release particles capsules |
| url | https://www.mdpi.com/1999-4923/15/5/1455 |
| work_keys_str_mv | AT jiaqiweng chitosanbasedparticulatecarriersstructureproductionandcorrespondingcontrolledrelease AT alaindurand chitosanbasedparticulatecarriersstructureproductionandcorrespondingcontrolledrelease AT stephanedesobry chitosanbasedparticulatecarriersstructureproductionandcorrespondingcontrolledrelease |