Photocrosslinkable natural polymers in tissue engineering
Natural polymers have been widely used in scaffolds for tissue engineering due to their superior biocompatibility, biodegradability, and low cytotoxicity compared to synthetic polymers. Despite these advantages, there remain drawbacks such as unsatisfying mechanical properties or low processability,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1127757/full |
| _version_ | 1811155039431950336 |
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| author | Seo Hyung Moon Hye Jin Hwang Hye Ryeong Jeon Sol Ji Park In Sun Bae Yun Jung Yang Yun Jung Yang |
| author_facet | Seo Hyung Moon Hye Jin Hwang Hye Ryeong Jeon Sol Ji Park In Sun Bae Yun Jung Yang Yun Jung Yang |
| author_sort | Seo Hyung Moon |
| collection | DOAJ |
| description | Natural polymers have been widely used in scaffolds for tissue engineering due to their superior biocompatibility, biodegradability, and low cytotoxicity compared to synthetic polymers. Despite these advantages, there remain drawbacks such as unsatisfying mechanical properties or low processability, which hinder natural tissue substitution. Several non-covalent or covalent crosslinking methods induced by chemicals, temperatures, pH, or light sources have been suggested to overcome these limitations. Among them, light-assisted crosslinking has been considered as a promising strategy for fabricating microstructures of scaffolds. This is due to the merits of non-invasiveness, relatively high crosslinking efficiency via light penetration, and easily controllable parameters, including light intensity or exposure time. This review focuses on photo-reactive moieties and their reaction mechanisms, which are widely exploited along with natural polymer and its tissue engineering applications. |
| first_indexed | 2024-04-10T04:26:19Z |
| format | Article |
| id | doaj.art-88158b67514f49869980e741a627bdda |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T04:26:19Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-88158b67514f49869980e741a627bdda2023-03-10T12:09:58ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11277571127757Photocrosslinkable natural polymers in tissue engineeringSeo Hyung Moon0Hye Jin Hwang1Hye Ryeong Jeon2Sol Ji Park3In Sun Bae4Yun Jung Yang5Yun Jung Yang6Department of Biological Sciences and Bioengineering, Inha University, Incheon, Republic of KoreaDepartment of Biological Sciences and Bioengineering, Inha University, Incheon, Republic of KoreaDepartment of Biological Engineering, Inha University, Incheon, Republic of KoreaDepartment of Biological Engineering, Inha University, Incheon, Republic of KoreaDepartment of Biological Sciences and Bioengineering, Inha University, Incheon, Republic of KoreaDepartment of Biological Sciences and Bioengineering, Inha University, Incheon, Republic of KoreaDepartment of Biological Engineering, Inha University, Incheon, Republic of KoreaNatural polymers have been widely used in scaffolds for tissue engineering due to their superior biocompatibility, biodegradability, and low cytotoxicity compared to synthetic polymers. Despite these advantages, there remain drawbacks such as unsatisfying mechanical properties or low processability, which hinder natural tissue substitution. Several non-covalent or covalent crosslinking methods induced by chemicals, temperatures, pH, or light sources have been suggested to overcome these limitations. Among them, light-assisted crosslinking has been considered as a promising strategy for fabricating microstructures of scaffolds. This is due to the merits of non-invasiveness, relatively high crosslinking efficiency via light penetration, and easily controllable parameters, including light intensity or exposure time. This review focuses on photo-reactive moieties and their reaction mechanisms, which are widely exploited along with natural polymer and its tissue engineering applications.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1127757/fullphoto-reactive moietyphoto-crosslinkingphotoinitiatorcatalystpolymerization |
| spellingShingle | Seo Hyung Moon Hye Jin Hwang Hye Ryeong Jeon Sol Ji Park In Sun Bae Yun Jung Yang Yun Jung Yang Photocrosslinkable natural polymers in tissue engineering Frontiers in Bioengineering and Biotechnology photo-reactive moiety photo-crosslinking photoinitiator catalyst polymerization |
| title | Photocrosslinkable natural polymers in tissue engineering |
| title_full | Photocrosslinkable natural polymers in tissue engineering |
| title_fullStr | Photocrosslinkable natural polymers in tissue engineering |
| title_full_unstemmed | Photocrosslinkable natural polymers in tissue engineering |
| title_short | Photocrosslinkable natural polymers in tissue engineering |
| title_sort | photocrosslinkable natural polymers in tissue engineering |
| topic | photo-reactive moiety photo-crosslinking photoinitiator catalyst polymerization |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1127757/full |
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