Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma
Background: Airway hyperresponsiveness (AHR) is a key feature of asthma and can be detected using various bronchoprovocation tests. In pediatric populations, the percentage of a positive methacholine challenge test (MCCTs) in children with asthma varies among studies, and some have reported seasonal...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217303224 |
| _version_ | 1811221902931263488 |
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| author | Shu-Jung Huang Li-Lun Lin Li-Chen Chen Liang-Shiou Ou Tsung-Chieh Yao Kuo-Chien Tsao Kuo-Wei Yeh Jing-Long Huang |
| author_facet | Shu-Jung Huang Li-Lun Lin Li-Chen Chen Liang-Shiou Ou Tsung-Chieh Yao Kuo-Chien Tsao Kuo-Wei Yeh Jing-Long Huang |
| author_sort | Shu-Jung Huang |
| collection | DOAJ |
| description | Background: Airway hyperresponsiveness (AHR) is a key feature of asthma and can be detected using various bronchoprovocation tests. In pediatric populations, the percentage of a positive methacholine challenge test (MCCTs) in children with asthma varies among studies, and some have reported seasonal variability. However, these studies have mostly been conducted in temperate regions.This study evaluated the prevalence of AHR to methacholine and its seasonal variation in asthmatic children in Taiwan, a subtropical country. Methods: A total of 276 children with asthma and their MCCT results were retrospectively reviewed. All were diagnosed with asthma and received asthma controllers regularly. They were assigned to four season groups depending in which season MCCTs were administered, with seasons categorized by the Central Weather Bureau of Taiwan. Subgroup analyses, including for sex, age, and atopy level, were compared for seasonal difference. Results: The prevalence of methacholine hyperresponsiveness was 70.7% (n = 195), and the children who were younger and had higher total serum IgE were more sensitive to methacholine (p = 0.019 and p < 0.005, respectively). No significant difference in AHR prevalence among seasons was observed (p = 0.480). The percentage of borderline, mild, and moderate severity of MCCT results was almost equally distributed among the seasons. In subgroup analysis, the children with a higher IgE level (≥75th percentile of all data) had a higher proportion of positive MCCTs in summer (88.6%, p = 0.016). Conclusion: In total, 70% of the children with asthma in Taiwan had AHR to methacholine, which varied among seasons. Children with a higher total serum IgE level may be more seasonally dependent, particularly in summer. Key Words: airway hyperresponsiveness, childhood asthma, methacholine |
| first_indexed | 2024-04-12T08:07:53Z |
| format | Article |
| id | doaj.art-88161331b0a8476b8e8f969577f80986 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-04-12T08:07:53Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-88161331b0a8476b8e8f969577f809862022-12-22T03:41:05ZengElsevierPediatrics and Neonatology1875-95722018-12-01596561566Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthmaShu-Jung Huang0Li-Lun Lin1Li-Chen Chen2Liang-Shiou Ou3Tsung-Chieh Yao4Kuo-Chien Tsao5Kuo-Wei Yeh6Jing-Long Huang7Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, TaiwanDepartment of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taiwan; Department of Biotechnology & Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, No.5, Fuxing St, Guishan Dist, Taoyuan City 333, Taoyuan, Taiwan. Fax: +886 3 3288957.Background: Airway hyperresponsiveness (AHR) is a key feature of asthma and can be detected using various bronchoprovocation tests. In pediatric populations, the percentage of a positive methacholine challenge test (MCCTs) in children with asthma varies among studies, and some have reported seasonal variability. However, these studies have mostly been conducted in temperate regions.This study evaluated the prevalence of AHR to methacholine and its seasonal variation in asthmatic children in Taiwan, a subtropical country. Methods: A total of 276 children with asthma and their MCCT results were retrospectively reviewed. All were diagnosed with asthma and received asthma controllers regularly. They were assigned to four season groups depending in which season MCCTs were administered, with seasons categorized by the Central Weather Bureau of Taiwan. Subgroup analyses, including for sex, age, and atopy level, were compared for seasonal difference. Results: The prevalence of methacholine hyperresponsiveness was 70.7% (n = 195), and the children who were younger and had higher total serum IgE were more sensitive to methacholine (p = 0.019 and p < 0.005, respectively). No significant difference in AHR prevalence among seasons was observed (p = 0.480). The percentage of borderline, mild, and moderate severity of MCCT results was almost equally distributed among the seasons. In subgroup analysis, the children with a higher IgE level (≥75th percentile of all data) had a higher proportion of positive MCCTs in summer (88.6%, p = 0.016). Conclusion: In total, 70% of the children with asthma in Taiwan had AHR to methacholine, which varied among seasons. Children with a higher total serum IgE level may be more seasonally dependent, particularly in summer. Key Words: airway hyperresponsiveness, childhood asthma, methacholinehttp://www.sciencedirect.com/science/article/pii/S1875957217303224 |
| spellingShingle | Shu-Jung Huang Li-Lun Lin Li-Chen Chen Liang-Shiou Ou Tsung-Chieh Yao Kuo-Chien Tsao Kuo-Wei Yeh Jing-Long Huang Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma Pediatrics and Neonatology |
| title | Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma |
| title_full | Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma |
| title_fullStr | Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma |
| title_full_unstemmed | Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma |
| title_short | Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma |
| title_sort | prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217303224 |
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