Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old
Cheng Ren,* Ming Li,* Teng Ma, Yi-Bo Xu, Zhong Li, Han-Zhong Xue, Qian Wang, Yao Lu, Liang Sun, Kun Zhang Department of Orthopedic Trauma, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China*These authors contributed equally to thi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-11-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/nonspecific-st-segment-and-t-wave-ns-stt-on-electrocardiogram-is-assoc-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818400588134612992 |
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| author | Ren C Li M Ma T Xu YB Li Z Xue HZ Wang Q Lu Y Sun L Zhang K |
| author_facet | Ren C Li M Ma T Xu YB Li Z Xue HZ Wang Q Lu Y Sun L Zhang K |
| author_sort | Ren C |
| collection | DOAJ |
| description | Cheng Ren,* Ming Li,* Teng Ma, Yi-Bo Xu, Zhong Li, Han-Zhong Xue, Qian Wang, Yao Lu, Liang Sun, Kun Zhang Department of Orthopedic Trauma, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kun ZhangDepartment of Orthopedic Trauma, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaEmail hhzhangkun@163.comObjective: This study aims to explore the clinical correlation between nonspecific ST-segment or T-wave (NS-STT) changes and perioperative deep vein thrombosis (DVT) in patients with lower extremity fractures.Methods: One thousand four hundred sixty-nine consecutive patients who suffered lower extremity fractures were screened at Xi’an Honghui Hospital between Feb 2016 and Nov 2018. According to the included and excluded criteria, the patients were included in this retrospective study. After collecting the electrocardiogram baseline, the patients were divided into the NS-STT group and the non-NS-STT group. After comparing the demographic and clinical characteristics, multivariate logistic regression models were used to identify the role of NS-STT changes on perioperative DVT. All analyses were performed with R and EmpowerStats software.Results: Nine hundred and sixty-eight patients were included in the study. Ninety-seven patients (10.02%) had NS-STT changes on the electrocardiogram at admission. A total of 303 patients (31.30%) developed perioperative DVT in lower extremities. The univariate analysis showed that NS-STT segment changes were correlated with perioperative DVT significantly (OR = 3.45, 95% CI: 2.25– 5.30, P < 0.0001). In addition, age ≥ 50 (P < 0.0001), female (OR = 1.50, 95% CI: 1.14– 1.97, P = 0.0038), hypertension (OR = 1.54, 95% CI: 1.08– 2.20, P = 0.0161), blood transfusion (OR = 1.78, 95% CI: 1.34– 2.37, P < 0.0001), joint prosthesis (OR = 3.26, 95% CI: 2.21– 4.81, P < 0.0001), and blood loss ≥ 300 mL (OR = 2.12, 95% CI: 1.50– 3.01, P < 0.0001) were associated with perioperative DVT in lower extremities. We identified the confounding factors of age, gender, classification of internal implants, operation time, blood loss, and infusion. After adjustment for potential confounding factors, NS-STT changes were associated with perioperative DVT (OR = 2.13, 95% CI: 1.33– 3.42; P = 0.0017). The sensitive analysis showed that the result was stable.Conclusion: The NS-STT changes on electrocardiograms are associated with an increase in the incidence of perioperative DVT by 2.13-fold in patients with lower extremity fractures under 75 years old. In clinical practice, surgeons should pay more attention to these patients.Keywords: nonspecific ST-segment and T-wave, NS-STT, electrocardiogram, DVT, lower extremity fracture, logistic regression |
| first_indexed | 2024-12-14T07:38:57Z |
| format | Article |
| id | doaj.art-8816447130134f5e961f4bada6f8d7f9 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-14T07:38:57Z |
| publishDate | 2021-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-8816447130134f5e961f4bada6f8d7f92022-12-21T23:11:05ZengDove Medical PressInternational Journal of General Medicine1178-70742021-11-01Volume 148631864170812Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years OldRen CLi MMa TXu YBLi ZXue HZWang QLu YSun LZhang KCheng Ren,* Ming Li,* Teng Ma, Yi-Bo Xu, Zhong Li, Han-Zhong Xue, Qian Wang, Yao Lu, Liang Sun, Kun Zhang Department of Orthopedic Trauma, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kun ZhangDepartment of Orthopedic Trauma, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaEmail hhzhangkun@163.comObjective: This study aims to explore the clinical correlation between nonspecific ST-segment or T-wave (NS-STT) changes and perioperative deep vein thrombosis (DVT) in patients with lower extremity fractures.Methods: One thousand four hundred sixty-nine consecutive patients who suffered lower extremity fractures were screened at Xi’an Honghui Hospital between Feb 2016 and Nov 2018. According to the included and excluded criteria, the patients were included in this retrospective study. After collecting the electrocardiogram baseline, the patients were divided into the NS-STT group and the non-NS-STT group. After comparing the demographic and clinical characteristics, multivariate logistic regression models were used to identify the role of NS-STT changes on perioperative DVT. All analyses were performed with R and EmpowerStats software.Results: Nine hundred and sixty-eight patients were included in the study. Ninety-seven patients (10.02%) had NS-STT changes on the electrocardiogram at admission. A total of 303 patients (31.30%) developed perioperative DVT in lower extremities. The univariate analysis showed that NS-STT segment changes were correlated with perioperative DVT significantly (OR = 3.45, 95% CI: 2.25– 5.30, P < 0.0001). In addition, age ≥ 50 (P < 0.0001), female (OR = 1.50, 95% CI: 1.14– 1.97, P = 0.0038), hypertension (OR = 1.54, 95% CI: 1.08– 2.20, P = 0.0161), blood transfusion (OR = 1.78, 95% CI: 1.34– 2.37, P < 0.0001), joint prosthesis (OR = 3.26, 95% CI: 2.21– 4.81, P < 0.0001), and blood loss ≥ 300 mL (OR = 2.12, 95% CI: 1.50– 3.01, P < 0.0001) were associated with perioperative DVT in lower extremities. We identified the confounding factors of age, gender, classification of internal implants, operation time, blood loss, and infusion. After adjustment for potential confounding factors, NS-STT changes were associated with perioperative DVT (OR = 2.13, 95% CI: 1.33– 3.42; P = 0.0017). The sensitive analysis showed that the result was stable.Conclusion: The NS-STT changes on electrocardiograms are associated with an increase in the incidence of perioperative DVT by 2.13-fold in patients with lower extremity fractures under 75 years old. In clinical practice, surgeons should pay more attention to these patients.Keywords: nonspecific ST-segment and T-wave, NS-STT, electrocardiogram, DVT, lower extremity fracture, logistic regressionhttps://www.dovepress.com/nonspecific-st-segment-and-t-wave-ns-stt-on-electrocardiogram-is-assoc-peer-reviewed-fulltext-article-IJGMnonspecific st-segment and t-wavens-sttelectrocardiogramdvtlower extremity fracturelogistic regression |
| spellingShingle | Ren C Li M Ma T Xu YB Li Z Xue HZ Wang Q Lu Y Sun L Zhang K Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old International Journal of General Medicine nonspecific st-segment and t-wave ns-stt electrocardiogram dvt lower extremity fracture logistic regression |
| title | Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old |
| title_full | Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old |
| title_fullStr | Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old |
| title_full_unstemmed | Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old |
| title_short | Nonspecific ST-Segment and T-Wave (NS-STT) on Electrocardiogram is Associated with Increasing the Incidence of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Fracture Under 75 Years Old |
| title_sort | nonspecific st segment and t wave ns stt on electrocardiogram is associated with increasing the incidence of perioperative deep vein thrombosis in patients with lower extremity fracture under 75 years old |
| topic | nonspecific st-segment and t-wave ns-stt electrocardiogram dvt lower extremity fracture logistic regression |
| url | https://www.dovepress.com/nonspecific-st-segment-and-t-wave-ns-stt-on-electrocardiogram-is-assoc-peer-reviewed-fulltext-article-IJGM |
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