Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics
ObjectiveTo establish bovine corneal opacity and permeability （BCOP） test， and determine its predictive ability for the eye irritation evaluation of cosmetics.MethodsA total of ten reference chemicals were selected to establish the BCOP test. Then eye irritation of 16 routinely collected cosmetics i...
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| Format: | Article |
| Language: | zho |
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Shanghai Preventive Medicine Association
2022-02-01
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| Series: | Shanghai yufang yixue |
| Subjects: | |
| Online Access: | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.21430 |
| _version_ | 1827246028386992128 |
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| author | HUO Qian SHA Yijie XIAO Ping HONG Xinyu WANG Letian ZHENG Weidong WEI Qi DONG Cheng TAO Gonghua |
| author_facet | HUO Qian SHA Yijie XIAO Ping HONG Xinyu WANG Letian ZHENG Weidong WEI Qi DONG Cheng TAO Gonghua |
| author_sort | HUO Qian |
| collection | DOAJ |
| description | ObjectiveTo establish bovine corneal opacity and permeability （BCOP） test， and determine its predictive ability for the eye irritation evaluation of cosmetics.MethodsA total of ten reference chemicals were selected to establish the BCOP test. Then eye irritation of 16 routinely collected cosmetics in our laboratory was predicted. In vitro scores were calculated by the change in the opacity and sodium fluorescein permeability after exposure to the testing cosmetics， and subsequently compared with the historical data by Draize test.ResultsReference chemicals with known irritation classification were correctly classified by the BCOP test， which was consistent with the classification of UN globally harmonized system of classification and labeling of chemicals. Moreover， the specificity of the BCOP test for the classification of non-irritating cosmetics samples was 80.0% （8/10）， and the sensitivity for weak to mild irritating cosmetics samples was 83.3% （5/6）. The BCOP test demonstrated an overall classification consistency of 81.3% （13/16） with in vivo test.ConclusionBCOP test may be independently used to identify chemicals with potential eye irritation and serious eye damage， suggesting it is significant for in vitro integrated test strategy for predicting eye irritation due to cosmetics. |
| first_indexed | 2024-04-10T19:13:34Z |
| format | Article |
| id | doaj.art-88174028306f4c02a96a024ddd94c44d |
| institution | Directory Open Access Journal |
| issn | 1004-9231 |
| language | zho |
| last_indexed | 2025-03-21T22:53:27Z |
| publishDate | 2022-02-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj.art-88174028306f4c02a96a024ddd94c44d2024-05-23T11:39:47ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312022-02-0134218318610.19428/j.cnki.sjpm.2022.214301004-9231（2022）02-0183-04Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmeticsHUO Qian0SHA Yijie1XIAO Ping2HONG Xinyu3WANG Letian4ZHENG Weidong5WEI Qi6DONG Cheng7TAO Gonghua8Division of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaDivision of Chemical Toxicity & Safety Assessment， Shanghai Municipal Center for Disease Control & Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics， Shanghai 200336， ChinaObjectiveTo establish bovine corneal opacity and permeability （BCOP） test， and determine its predictive ability for the eye irritation evaluation of cosmetics.MethodsA total of ten reference chemicals were selected to establish the BCOP test. Then eye irritation of 16 routinely collected cosmetics in our laboratory was predicted. In vitro scores were calculated by the change in the opacity and sodium fluorescein permeability after exposure to the testing cosmetics， and subsequently compared with the historical data by Draize test.ResultsReference chemicals with known irritation classification were correctly classified by the BCOP test， which was consistent with the classification of UN globally harmonized system of classification and labeling of chemicals. Moreover， the specificity of the BCOP test for the classification of non-irritating cosmetics samples was 80.0% （8/10）， and the sensitivity for weak to mild irritating cosmetics samples was 83.3% （5/6）. The BCOP test demonstrated an overall classification consistency of 81.3% （13/16） with in vivo test.ConclusionBCOP test may be independently used to identify chemicals with potential eye irritation and serious eye damage， suggesting it is significant for in vitro integrated test strategy for predicting eye irritation due to cosmetics.http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.21430bovine corneal opacity and permeability test （bcop）eye irritationcosmetics |
| spellingShingle | HUO Qian SHA Yijie XIAO Ping HONG Xinyu WANG Letian ZHENG Weidong WEI Qi DONG Cheng TAO Gonghua Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics Shanghai yufang yixue bovine corneal opacity and permeability test （bcop） eye irritation cosmetics |
| title | Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics |
| title_full | Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics |
| title_fullStr | Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics |
| title_full_unstemmed | Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics |
| title_short | Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics |
| title_sort | application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics |
| topic | bovine corneal opacity and permeability test （bcop） eye irritation cosmetics |
| url | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.21430 |
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