MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY
An article reflects modern concepts of the etiology of vitamin B12 deficiency including medication-induced conditions. Particular attention is paid to diagnostic algorithm in case of overt and latent forms of deficit. As the method of choice for the diagnosis of vitamin B12 deficiency it is recommen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2017-01-01
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| Series: | Klinicist |
| Subjects: | |
| Online Access: | https://klinitsist.abvpress.ru/Klin/article/view/272 |
| _version_ | 1797855612813443072 |
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| author | A. L. Krasnovskiy S. P. Grigor’iev R. M. Alyokhina I. S. Ezhova I. V. Zolkina E. O. Loshkareva |
| author_facet | A. L. Krasnovskiy S. P. Grigor’iev R. M. Alyokhina I. S. Ezhova I. V. Zolkina E. O. Loshkareva |
| author_sort | A. L. Krasnovskiy |
| collection | DOAJ |
| description | An article reflects modern concepts of the etiology of vitamin B12 deficiency including medication-induced conditions. Particular attention is paid to diagnostic algorithm in case of overt and latent forms of deficit. As the method of choice for the diagnosis of vitamin B12 deficiency it is recommended to determine the level of holotranscobalamin and use additional methods for detecting metabolic deficiency of vitamin B12 – to study the levels of homocysteine and methylmalonic acid. Diagnostic algorithms for patients with clinical suspicion of vitamin B12 deficiency and the presence of subclinical deficiency. We reviewed the possibility of vitamin B12 oral preparations to correct low levels of cobalamin in asymptomatic patients, as well as maintenance therapy in patients with clinical signs of vitamin B12 deficiency. |
| first_indexed | 2024-04-09T20:26:44Z |
| format | Article |
| id | doaj.art-8817d8845356445fad1aaa830ad4db9c |
| institution | Directory Open Access Journal |
| issn | 1818-8338 |
| language | Russian |
| last_indexed | 2024-04-09T20:26:44Z |
| publishDate | 2017-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Klinicist |
| spelling | doaj.art-8817d8845356445fad1aaa830ad4db9c2023-03-30T20:14:09ZrusABV-pressKlinicist1818-83382017-01-01103152510.17650/1818-8338-2016-10-3-15-25248MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCYA. L. Krasnovskiy0S. P. Grigor’iev1R. M. Alyokhina2I. S. Ezhova3I. V. Zolkina4E. O. Loshkareva5State Budgetary Educational Institution N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaState Budgetary Educational Institution N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaState Budgetary Educational Institution N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaState Budgetary Educational Institution N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaState Budgetary Educational Institution N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaState Budgetary Educational Institution N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaAn article reflects modern concepts of the etiology of vitamin B12 deficiency including medication-induced conditions. Particular attention is paid to diagnostic algorithm in case of overt and latent forms of deficit. As the method of choice for the diagnosis of vitamin B12 deficiency it is recommended to determine the level of holotranscobalamin and use additional methods for detecting metabolic deficiency of vitamin B12 – to study the levels of homocysteine and methylmalonic acid. Diagnostic algorithms for patients with clinical suspicion of vitamin B12 deficiency and the presence of subclinical deficiency. We reviewed the possibility of vitamin B12 oral preparations to correct low levels of cobalamin in asymptomatic patients, as well as maintenance therapy in patients with clinical signs of vitamin B12 deficiency.https://klinitsist.abvpress.ru/Klin/article/view/272vitamin b12 deficiencyetiology of vitamin b12 deficiencyb12-deficiency anemiaatrophic autoimmune gastritismacrocytic anemiaintrinsic factordiagnosis of latent forms of vitamin b12 deficiencyholotranscobalaminhomocysteinemethylmalonic acidalgorithms for the management of patients with vitamin b12 deficiencyoral vitamin b12 formulationshydroxocobalamincyanocobalaminpernicious anema |
| spellingShingle | A. L. Krasnovskiy S. P. Grigor’iev R. M. Alyokhina I. S. Ezhova I. V. Zolkina E. O. Loshkareva MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY Klinicist vitamin b12 deficiency etiology of vitamin b12 deficiency b12-deficiency anemia atrophic autoimmune gastritis macrocytic anemia intrinsic factor diagnosis of latent forms of vitamin b12 deficiency holotranscobalamin homocysteine methylmalonic acid algorithms for the management of patients with vitamin b12 deficiency oral vitamin b12 formulations hydroxocobalamin cyanocobalamin pernicious anema |
| title | MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY |
| title_full | MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY |
| title_fullStr | MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY |
| title_full_unstemmed | MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY |
| title_short | MODERN DIAGNOSTIC AND TREATMENT OF VITAMIN В12 DEFICIENCY |
| title_sort | modern diagnostic and treatment of vitamin в12 deficiency |
| topic | vitamin b12 deficiency etiology of vitamin b12 deficiency b12-deficiency anemia atrophic autoimmune gastritis macrocytic anemia intrinsic factor diagnosis of latent forms of vitamin b12 deficiency holotranscobalamin homocysteine methylmalonic acid algorithms for the management of patients with vitamin b12 deficiency oral vitamin b12 formulations hydroxocobalamin cyanocobalamin pernicious anema |
| url | https://klinitsist.abvpress.ru/Klin/article/view/272 |
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