TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability

Abstract Background Metabolic reprogramming is a hallmark of various cancers. Targeting metabolic processes is a very attractive treatment for cancer. Renal cell carcinoma (RCC) is a type of metabolic disease, and the lipidomic profile of RCC is significantly altered compared with that of healthy ti...

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Bibliographic Details
Main Authors: Xintian Chen, Hongmei Yong, Miaolei Chen, Chuyin Deng, Pengfei Wang, Sufang Chu, Minle Li, Pingfu Hou, Junnian Zheng, Zhongwei Li, Jin Bai
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TRIM21
Lipogenesis
SREBF1
Ubiquitination
Renal cell carcinoma
Online Access:https://doi.org/10.1186/s13046-022-02583-z

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