Silymarin: a review on paving the way towards promising pharmacological agent
ABSTRACTAdvancements in the field of research and development have paved toward the use of herbal agents to cure and control health maladies. Milk thistle (Silybum marianum L.) is one of the herbs that possess pharmacological and therapeutic attributes. Various bioactive components in milk thistle h...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-09-01
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| Series: | International Journal of Food Properties |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2244685 |
| _version_ | 1797202472205287424 |
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| author | Muhmmad Nadeem Akhtar Rabia Saeed Farhan Saeed Aasma Asghar Samia Ghani Huda Ateeq Aftab Ahmed Amara Rasheed Muhammad Afzaal Marwa Waheed Bilal Hussain Mohd Asif Shah |
| author_facet | Muhmmad Nadeem Akhtar Rabia Saeed Farhan Saeed Aasma Asghar Samia Ghani Huda Ateeq Aftab Ahmed Amara Rasheed Muhammad Afzaal Marwa Waheed Bilal Hussain Mohd Asif Shah |
| author_sort | Muhmmad Nadeem Akhtar |
| collection | DOAJ |
| description | ABSTRACTAdvancements in the field of research and development have paved toward the use of herbal agents to cure and control health maladies. Milk thistle (Silybum marianum L.) is one of the herbs that possess pharmacological and therapeutic attributes. Various bioactive components in milk thistle have a key role in pathological conditions like blood-related disorders, hepatic ailments, arthritis, ulcerative colitis, and carcinomas. Among various bioactive components, silymarin is an active agent which isa standardized mixture of flavonolignans (70%–80%) along with silybin, silydianin, and silychristin, with silybin being the main active chemical component. Silymarin has been used medicinally to treat liver disorders, including acute and chronic viral hepatitis, toxin/drug-induced hepatitis, cirrhosis, and alcoholic liver diseases. Traditionally, the plant was employed to increase human reproduction ability, possess reactive oxygen species (ROS) scavenging, antioxidant, anti-inflammatory and immunomodulatory properties, has UV-induced skin damage protection, maintains the menstrual cycle, lessen viral infection, decrease fibrosis, and blood glucose as well as improve functions of the liver, pancreas, and reproductive cells. This review summarizes the basic as well as advanced therapeutic effects of silymarin which will ultimately lead researchers in developinphytopharmaceutical-based complementary medicine. |
| first_indexed | 2024-03-11T18:20:14Z |
| format | Article |
| id | doaj.art-8818e2e987374799b9aae061b9034632 |
| institution | Directory Open Access Journal |
| issn | 1094-2912 1532-2386 |
| language | English |
| last_indexed | 2024-04-24T08:03:59Z |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj.art-8818e2e987374799b9aae061b90346322024-04-17T13:20:13ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-012612256227210.1080/10942912.2023.2244685Silymarin: a review on paving the way towards promising pharmacological agentMuhmmad Nadeem Akhtar0Rabia Saeed1Farhan Saeed2Aasma Asghar3Samia Ghani4Huda Ateeq5Aftab Ahmed6Amara Rasheed7Muhammad Afzaal8Marwa Waheed9Bilal Hussain10Mohd Asif Shah11Faculty of Allied Health Science, University Institute of Diet and Nutritional Sciences, Lahore, PakistanDepartment of Microbiology, University of Health Sciences, Lahore, PakistanFood Safety and Biotechnology Laboratory, Department of Food Science, Government College University, Faisalabad, PakistanDepartment of Nutritional Sciences, Government College University, Faisalabad, PakistanFaculty of Pharmaceutical Sciences, Government College University, Faisalabad, PakistanFood Safety and Biotechnology Laboratory, Department of Food Science, Government College University, Faisalabad, PakistanDepartment of Nutritional Sciences, Government College University, Faisalabad, PakistanFood Safety and Biotechnology Laboratory, Department of Food Science, Government College University, Faisalabad, PakistanDepartment of Microbiology, University of Health Sciences, Lahore, PakistanFood Safety and Biotechnology Laboratory, Department of Food Science, Government College University, Faisalabad, PakistanFood Safety and Biotechnology Laboratory, Department of Food Science, Government College University, Faisalabad, PakistanDepartment of Economics, College of Business and Economics, Kebri Dehar University, Somali, EthiopiaABSTRACTAdvancements in the field of research and development have paved toward the use of herbal agents to cure and control health maladies. Milk thistle (Silybum marianum L.) is one of the herbs that possess pharmacological and therapeutic attributes. Various bioactive components in milk thistle have a key role in pathological conditions like blood-related disorders, hepatic ailments, arthritis, ulcerative colitis, and carcinomas. Among various bioactive components, silymarin is an active agent which isa standardized mixture of flavonolignans (70%–80%) along with silybin, silydianin, and silychristin, with silybin being the main active chemical component. Silymarin has been used medicinally to treat liver disorders, including acute and chronic viral hepatitis, toxin/drug-induced hepatitis, cirrhosis, and alcoholic liver diseases. Traditionally, the plant was employed to increase human reproduction ability, possess reactive oxygen species (ROS) scavenging, antioxidant, anti-inflammatory and immunomodulatory properties, has UV-induced skin damage protection, maintains the menstrual cycle, lessen viral infection, decrease fibrosis, and blood glucose as well as improve functions of the liver, pancreas, and reproductive cells. This review summarizes the basic as well as advanced therapeutic effects of silymarin which will ultimately lead researchers in developinphytopharmaceutical-based complementary medicine.https://www.tandfonline.com/doi/10.1080/10942912.2023.2244685Herbsntritionpharmacologicalsilybum marianumhealth modalitiestherapeutic potential |
| spellingShingle | Muhmmad Nadeem Akhtar Rabia Saeed Farhan Saeed Aasma Asghar Samia Ghani Huda Ateeq Aftab Ahmed Amara Rasheed Muhammad Afzaal Marwa Waheed Bilal Hussain Mohd Asif Shah Silymarin: a review on paving the way towards promising pharmacological agent International Journal of Food Properties Herbs ntrition pharmacological silybum marianum health modalities therapeutic potential |
| title | Silymarin: a review on paving the way towards promising pharmacological agent |
| title_full | Silymarin: a review on paving the way towards promising pharmacological agent |
| title_fullStr | Silymarin: a review on paving the way towards promising pharmacological agent |
| title_full_unstemmed | Silymarin: a review on paving the way towards promising pharmacological agent |
| title_short | Silymarin: a review on paving the way towards promising pharmacological agent |
| title_sort | silymarin a review on paving the way towards promising pharmacological agent |
| topic | Herbs ntrition pharmacological silybum marianum health modalities therapeutic potential |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2244685 |
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