Functional Outcomes of Cerebellar Malformations
The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the di...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-10-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00441/full |
| _version_ | 1819150306371436544 |
|---|---|
| author | Jason S. Gill Jason S. Gill Jason S. Gill Roy V. Sillitoe Roy V. Sillitoe Roy V. Sillitoe |
| author_facet | Jason S. Gill Jason S. Gill Jason S. Gill Roy V. Sillitoe Roy V. Sillitoe Roy V. Sillitoe |
| author_sort | Jason S. Gill |
| collection | DOAJ |
| description | The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behaviors that it can influence, it is therefore not surprising that cerebellar dysfunction is linked to motor diseases such as ataxia, dystonia, tremor, and Parkinson’s disease as well to non-motor disorders including autism spectrum disorders (ASD), schizophrenia, depression, and anxiety. Regardless of the condition, there is a growing consensus that developmental disturbances of the cerebellum may be a central culprit in triggering a number of distinct pathophysiological processes. Here, we consider how cerebellar malformations and neuronal circuit wiring impact brain function and behavior during development. We use the cerebellum as a model to discuss the expanding view that local integrated brain circuits function within the context of distributed global networks to communicate the computations that drive complex behavior. We highlight growing concerns that neurological and neuropsychiatric diseases with severe behavioral outcomes originate from developmental insults to the cerebellum. |
| first_indexed | 2024-12-22T14:15:24Z |
| format | Article |
| id | doaj.art-88190bddae754022a6f9516e1c4b6fdf |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T14:15:24Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-88190bddae754022a6f9516e1c4b6fdf2022-12-21T18:23:08ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-10-011310.3389/fncel.2019.00441488682Functional Outcomes of Cerebellar MalformationsJason S. Gill0Jason S. Gill1Jason S. Gill2Roy V. Sillitoe3Roy V. Sillitoe4Roy V. Sillitoe5Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, TX, United StatesDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesJan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, United StatesDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesJan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, United StatesDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, United StatesThe cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behaviors that it can influence, it is therefore not surprising that cerebellar dysfunction is linked to motor diseases such as ataxia, dystonia, tremor, and Parkinson’s disease as well to non-motor disorders including autism spectrum disorders (ASD), schizophrenia, depression, and anxiety. Regardless of the condition, there is a growing consensus that developmental disturbances of the cerebellum may be a central culprit in triggering a number of distinct pathophysiological processes. Here, we consider how cerebellar malformations and neuronal circuit wiring impact brain function and behavior during development. We use the cerebellum as a model to discuss the expanding view that local integrated brain circuits function within the context of distributed global networks to communicate the computations that drive complex behavior. We highlight growing concerns that neurological and neuropsychiatric diseases with severe behavioral outcomes originate from developmental insults to the cerebellum.https://www.frontiersin.org/article/10.3389/fncel.2019.00441/fullcerebellumdevelopmentPurkinje cellcerebellar nucleicircuitrymotor |
| spellingShingle | Jason S. Gill Jason S. Gill Jason S. Gill Roy V. Sillitoe Roy V. Sillitoe Roy V. Sillitoe Functional Outcomes of Cerebellar Malformations Frontiers in Cellular Neuroscience cerebellum development Purkinje cell cerebellar nuclei circuitry motor |
| title | Functional Outcomes of Cerebellar Malformations |
| title_full | Functional Outcomes of Cerebellar Malformations |
| title_fullStr | Functional Outcomes of Cerebellar Malformations |
| title_full_unstemmed | Functional Outcomes of Cerebellar Malformations |
| title_short | Functional Outcomes of Cerebellar Malformations |
| title_sort | functional outcomes of cerebellar malformations |
| topic | cerebellum development Purkinje cell cerebellar nuclei circuitry motor |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00441/full |
| work_keys_str_mv | AT jasonsgill functionaloutcomesofcerebellarmalformations AT jasonsgill functionaloutcomesofcerebellarmalformations AT jasonsgill functionaloutcomesofcerebellarmalformations AT royvsillitoe functionaloutcomesofcerebellarmalformations AT royvsillitoe functionaloutcomesofcerebellarmalformations AT royvsillitoe functionaloutcomesofcerebellarmalformations |