Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00730/full |
| _version_ | 1818318742909616128 |
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| author | Krzysztof Łopata Emilia Wojdas Emilia Wojdas Roman Nowak Paweł Łopata Urszula Mazurek |
| author_facet | Krzysztof Łopata Emilia Wojdas Emilia Wojdas Roman Nowak Paweł Łopata Urszula Mazurek |
| author_sort | Krzysztof Łopata |
| collection | DOAJ |
| description | The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk. |
| first_indexed | 2024-12-13T09:58:04Z |
| format | Article |
| id | doaj.art-881a440a19164768b603b699066baa27 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-13T09:58:04Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-881a440a19164768b603b699066baa272022-12-21T23:51:44ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-04-01910.3389/fmicb.2018.00730345412Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human CellsKrzysztof Łopata0Emilia Wojdas1Emilia Wojdas2Roman Nowak3Paweł Łopata4Urszula Mazurek5Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, PolandDepartment of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, PolandDepartment of Instrumental Analysis, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, PolandDepartment of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, PolandDepartment of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, PolandDepartment of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, PolandThe xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk.http://journal.frontiersin.org/article/10.3389/fmicb.2018.00730/fullporcine endogenous retrovirusxenotransplantationPERV molecular structurePERV biological cyclePERVPERV transmission risk |
| spellingShingle | Krzysztof Łopata Emilia Wojdas Emilia Wojdas Roman Nowak Paweł Łopata Urszula Mazurek Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells Frontiers in Microbiology porcine endogenous retrovirus xenotransplantation PERV molecular structure PERV biological cycle PERV PERV transmission risk |
| title | Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells |
| title_full | Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells |
| title_fullStr | Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells |
| title_full_unstemmed | Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells |
| title_short | Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells |
| title_sort | porcine endogenous retrovirus perv molecular structure and replication strategy in the context of retroviral infection risk of human cells |
| topic | porcine endogenous retrovirus xenotransplantation PERV molecular structure PERV biological cycle PERV PERV transmission risk |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00730/full |
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