Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study
Background: maxillary bone invasion (MBI) is not uncommon in hard palate or upper alveolus (HP/UA) cancer; however, there have been relatively few reports about the MBI of HP/UA cancer. Patients and Methods: this was a multi-center retrospective study, enrolling 144 cases of HP/UA cancer. MBI was de...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/19/4699 |
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| author | Nayeon Choi Jeon Yeob Jang Min-Ji Kim Sung Seok Ryu Young Ho Jung Han-Sin Jeong |
| author_facet | Nayeon Choi Jeon Yeob Jang Min-Ji Kim Sung Seok Ryu Young Ho Jung Han-Sin Jeong |
| author_sort | Nayeon Choi |
| collection | DOAJ |
| description | Background: maxillary bone invasion (MBI) is not uncommon in hard palate or upper alveolus (HP/UA) cancer; however, there have been relatively few reports about the MBI of HP/UA cancer. Patients and Methods: this was a multi-center retrospective study, enrolling 144 cases of HP/UA cancer. MBI was defined by surgical pathology or radiology follow-up. The multiple prediction models for MBI were developed in total cases and in cases having primary bone resection, using clinical and radiological variables. Results: computerized tomography (CT) alone predicted MBI, with an area under receiver operating curve (AUC) of 0.779 (95% confidence interval (CI) = 0.712–0.847). The AUC was increased in a model that combined tumor dimensions and clinical factors (male sex and nodal metastasis) (0.854 (95%CI = 0.790–0.918)). In patients who underwent <sup>18</sup>fluorodeoxyglucose positron emission tomography/CT (PET/CT), the discrimination performance of a model including the maximal standardized uptake value (SUVmax) had an AUC of 0.911 (95%CI = 0.847–0.975). The scoring system using CT finding, tumor dimension, and clinical factors, with/without PET/CT SUVmax clearly distinguished low-, intermediate-, and high-risk groups for MBI. Conclusion: using information from CT, tumor dimension, clinical factors, and the SUVmax value, the MBI of HP/UA cancer can be predicted with a relatively high discrimination performance. |
| first_indexed | 2024-03-10T21:48:44Z |
| format | Article |
| id | doaj.art-881a72dc55ff4a8b9fb191679960e305 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:48:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-881a72dc55ff4a8b9fb191679960e3052023-11-19T14:09:18ZengMDPI AGCancers2072-66942023-09-011519469910.3390/cancers15194699Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective StudyNayeon Choi0Jeon Yeob Jang1Min-Ji Kim2Sung Seok Ryu3Young Ho Jung4Han-Sin Jeong5Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 06351, Republic of KoreaDepartment of Otolaryngology, Ajou University Hospital, Ajou University School of Medicine, Suwon 16499, Republic of KoreaBiomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of KoreaDepartment of Otolaryngology, Ulsan University School of Medicine, Asan Medical Center, Seoul 05505, Republic of KoreaDepartment of Otolaryngology, Ulsan University School of Medicine, Asan Medical Center, Seoul 05505, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 06351, Republic of KoreaBackground: maxillary bone invasion (MBI) is not uncommon in hard palate or upper alveolus (HP/UA) cancer; however, there have been relatively few reports about the MBI of HP/UA cancer. Patients and Methods: this was a multi-center retrospective study, enrolling 144 cases of HP/UA cancer. MBI was defined by surgical pathology or radiology follow-up. The multiple prediction models for MBI were developed in total cases and in cases having primary bone resection, using clinical and radiological variables. Results: computerized tomography (CT) alone predicted MBI, with an area under receiver operating curve (AUC) of 0.779 (95% confidence interval (CI) = 0.712–0.847). The AUC was increased in a model that combined tumor dimensions and clinical factors (male sex and nodal metastasis) (0.854 (95%CI = 0.790–0.918)). In patients who underwent <sup>18</sup>fluorodeoxyglucose positron emission tomography/CT (PET/CT), the discrimination performance of a model including the maximal standardized uptake value (SUVmax) had an AUC of 0.911 (95%CI = 0.847–0.975). The scoring system using CT finding, tumor dimension, and clinical factors, with/without PET/CT SUVmax clearly distinguished low-, intermediate-, and high-risk groups for MBI. Conclusion: using information from CT, tumor dimension, clinical factors, and the SUVmax value, the MBI of HP/UA cancer can be predicted with a relatively high discrimination performance.https://www.mdpi.com/2072-6694/15/19/4699hard palatealveolar processneoplasmbonediagnostic imaging |
| spellingShingle | Nayeon Choi Jeon Yeob Jang Min-Ji Kim Sung Seok Ryu Young Ho Jung Han-Sin Jeong Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study Cancers hard palate alveolar process neoplasm bone diagnostic imaging |
| title | Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study |
| title_full | Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study |
| title_fullStr | Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study |
| title_full_unstemmed | Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study |
| title_short | Prediction of Maxillary Bone Invasion in Hard Palate/Upper Alveolus Cancer: A Multi-Center Retrospective Study |
| title_sort | prediction of maxillary bone invasion in hard palate upper alveolus cancer a multi center retrospective study |
| topic | hard palate alveolar process neoplasm bone diagnostic imaging |
| url | https://www.mdpi.com/2072-6694/15/19/4699 |
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