Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine
The edible red seaweed Eucheuma cottonii is widely cultivated throughout most of the tropical seas. Asthma affects over 300 million people worldwide and is related to airway inflammation, smooth muscle hypertrophy, mucous hyperplasia and hyper-secretion, and airway constriction. The therapeutic mech...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464615005083 |
| _version_ | 1819294296096899072 |
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| author | Nurul'Ain Abu Bakar Victor Uche Anyanji Noordin Mohamed Mustapha Swee-Ling Lim Suhaila Mohamed |
| author_facet | Nurul'Ain Abu Bakar Victor Uche Anyanji Noordin Mohamed Mustapha Swee-Ling Lim Suhaila Mohamed |
| author_sort | Nurul'Ain Abu Bakar |
| collection | DOAJ |
| description | The edible red seaweed Eucheuma cottonii is widely cultivated throughout most of the tropical seas. Asthma affects over 300 million people worldwide and is related to airway inflammation, smooth muscle hypertrophy, mucous hyperplasia and hyper-secretion, and airway constriction. The therapeutic mechanisms by which Eucheuma cottonii extract (SECE) reduced symptoms in experimental ovalbumin-induced allergic asthma animal model was compared to the FDA approved anti-histamine drug Loratadine. The extract significantly ameliorated nasal itching, sneezing, lung histopathology, immunohistochemistry and related genes changes. The SECE was anti-inflammatory and altered the circulating white blood cell levels. The SECE treatment decreased mucin synthesis, and downregulated the tumour necrosis factor-alpha (TNF-α), interleukin (IL)-4, nuclear factor kappa beta (NF-κB), epidermal growth factor receptor (EGFR) and matrix metalloproteinase (MMP)-9 expressions, but increased the interferon-gamma (IFN-γ) expression. The lectins-rich extract (FTIR analysed) suppressed asthmatic inflammation, lung eosinophil infiltration, and mucin synthesis, and reduced the bronchiole smooth muscle thickness to facilitate airway flow. |
| first_indexed | 2024-12-24T04:24:04Z |
| format | Article |
| id | doaj.art-881bf7411e324dc39f050883168ec8a8 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:24:04Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-881bf7411e324dc39f050883168ec8a82022-12-21T17:15:42ZengElsevierJournal of Functional Foods1756-46462015-12-0119710722Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to LoratadineNurul'Ain Abu Bakar0Victor Uche Anyanji1Noordin Mohamed Mustapha2Swee-Ling Lim3Suhaila Mohamed4Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaDepartment of Veterinary Pathology & Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaInstitute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaInstitute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Corresponding author. Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Tel.: +60 38947 2168; fax: +60 38947 2101.The edible red seaweed Eucheuma cottonii is widely cultivated throughout most of the tropical seas. Asthma affects over 300 million people worldwide and is related to airway inflammation, smooth muscle hypertrophy, mucous hyperplasia and hyper-secretion, and airway constriction. The therapeutic mechanisms by which Eucheuma cottonii extract (SECE) reduced symptoms in experimental ovalbumin-induced allergic asthma animal model was compared to the FDA approved anti-histamine drug Loratadine. The extract significantly ameliorated nasal itching, sneezing, lung histopathology, immunohistochemistry and related genes changes. The SECE was anti-inflammatory and altered the circulating white blood cell levels. The SECE treatment decreased mucin synthesis, and downregulated the tumour necrosis factor-alpha (TNF-α), interleukin (IL)-4, nuclear factor kappa beta (NF-κB), epidermal growth factor receptor (EGFR) and matrix metalloproteinase (MMP)-9 expressions, but increased the interferon-gamma (IFN-γ) expression. The lectins-rich extract (FTIR analysed) suppressed asthmatic inflammation, lung eosinophil infiltration, and mucin synthesis, and reduced the bronchiole smooth muscle thickness to facilitate airway flow.http://www.sciencedirect.com/science/article/pii/S1756464615005083AsthmaEucheuma cottoniiAnti-inflammatoryMucin synthesisLung eosinophil infiltrationLectins |
| spellingShingle | Nurul'Ain Abu Bakar Victor Uche Anyanji Noordin Mohamed Mustapha Swee-Ling Lim Suhaila Mohamed Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine Journal of Functional Foods Asthma Eucheuma cottonii Anti-inflammatory Mucin synthesis Lung eosinophil infiltration Lectins |
| title | Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine |
| title_full | Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine |
| title_fullStr | Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine |
| title_full_unstemmed | Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine |
| title_short | Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine |
| title_sort | seaweed eucheuma cottonii reduced inflammation mucin synthesis eosinophil infiltration and mmp 9 expressions in asthma induced rats compared to loratadine |
| topic | Asthma Eucheuma cottonii Anti-inflammatory Mucin synthesis Lung eosinophil infiltration Lectins |
| url | http://www.sciencedirect.com/science/article/pii/S1756464615005083 |
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